摘要
中国实施新生儿乙型肝炎(乙肝)疫苗(Hepatitis B vaccine,HepB)免疫规划以来,儿童乙肝表面抗原(Hepatitis B surface antigen,HBsAg)携带率显著降低。然而成人乙肝病毒(Hepatitis B virus,HBV)感染率和易感者比例仍然较高,而HepB接种率较低,可因多种高危行为或职业暴露增加HBV感染风险。本文综述了成人HBV感染的风险和疾病负担,以及成人高危人群接种HepB的必要性。
Since the introduction of hepatitis B vaccine(HepB)into the National Immunization Program in China,the prevalence of hepatitis B surface antigen(HBsAg)has declined significantly among children.However,the prevalence of chronic inf ection with hepatitis B virus(HBV)and the prevalence of HBV-susceptibility are still high among adults,while coverage with Hep B is low among adults.The risk of HBV infection is increasing among adults due to high-risk behaviors and occupational exposure.In this article,we review risk factors for and disease burden of adult HBV infection,and we discuss the necessity of HepB vaccination of high-risk adult populations.
作者
万咏梅
王富珍
张国民
崔富强
Wan Yongmei;Wang Fuzhen;Zhang Guomin;Cui Fuqiang(National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;School of Public Health,Peking University,Beijing 100191,China)
出处
《中国疫苗和免疫》
北大核心
2019年第5期611-616,共6页
Chinese Journal of Vaccines and Immunization
基金
中国成人高危人群和社区人群乙肝疫苗优化免疫策略研究(2018ZX10721202)
关键词
乙型肝炎
感染风险
疾病负担
成人
高危人群
Hepatitis B
Infection risk
Disease burden
Adult
High-risk population
