摘要
抗Jo-1抗体综合征又称抗组氨酰-tRNA合成酶综合征,是一种因自身肌炎特异性抗体功能紊乱而出现的临床症候群,可累及肺部、肌肉、关节等全身多脏器.抗Jo-1抗体综合征中70%~90%的患者伴间质性肺疾病,该病误诊率高,治疗效果不佳,易复发,5年生存率不足70%.为了提高对本病的认识,减少误诊和漏诊,本文就抗Jo-1抗体综合征的诊治进展作一综述.
Anti-Jo-1 syndrome,known as anti-hystroyl-tRNA synthetase syndrome,is a clinical syndrome caused by dysfunction of specific antibodies against automyositis,which involves multiple organs such as lungs,muscles and joints.70%to 90%of anti-Jo-1 syndrome patients have interstitial lung disease.Anti-Jo-1 syndrome has high misdiagnosis rate,poor treatment effect,easy recurrence,and the five-year survival rate is less than 70%.In order to improve the understanding of anti-Jo-1 syndrome,reduce misdiagnosis and missed diagnosis,the progress of diagnosis and treatment of anti-Jo-1 syndrome is summarized as follows.
作者
余雯文
吴立琴
戴元荣
Yu Wenwen;Wu Liqin;Dai Yuanrong(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027,China)
出处
《国际呼吸杂志》
2019年第21期1670-1674,共5页
International Journal of Respiration
关键词
抗Jo-1抗体综合征
肺疾病
间质性
发病机制
诊治
Anti-Jo-1 syndrome
Lung diseases,interstitial
Pathogenesis
Diagnosis and treatment
