摘要
目的调查三甲医院住院患儿用药医嘱超说明书情况,分析原因,并与同年门急诊超说明书用药发生率进行比较。方法自2018年1-12月,每月随机抽取营口市中心医院20例(共240例)住院患儿用药医嘱记录,统计其姓名、年龄、体重、药品用法用量等。结果 240例患儿,7 579条用药医嘱,其中3 075条医嘱有超说明书用药现象,超说明书用药发生率为40.57%。超说明书用药发生率较高的药品种类为调节水电解质、酸碱平衡以及抗感染药、维生素类和营养药。用药医嘱数排名前3的药品为头孢美唑钠注射液、碳酸氢钠注射液、乳糖酸红霉素注射液,其超说明书用药发生率分别为4.24%、98.02%、14.44%。结论超说明书用药情况在医院患儿中普遍存在,住院患儿的超说明书用药发生率高于门急诊,但是其药物种类差别较大。
Objective To investigate the off-label drug use of hospitalized children in first-class hospitals in 2018 and the causes were analyzed, by comparing with the incidence of off-label drug use in outpatient and emergency department. Methods From January to December 2018, a total of 20 cases(240 cases) of pediatric inpatients in Yingkou Central Hospital were randomly sampled and their names, ages, weights, usage and dosage of drugs were counted. Results Among 240 children, 7579 medication orders were issued, of which 3075 exceeded the instructions. The incidence of drug use exceeding the instructions was 40.57%. Among the off-label drugs, the higher incidence of off-label drugs were regulating water electrolyte, acid-base balance, anti-infective drugs, vitamins and nutritional drugs. Cefmetazole sodium injection, sodium bicarbonate injection and erythromycin lactate injection ranked the top 3 in terms of the number of drugs ordered by doctors. The off-label drug use rate was 4.24%, 98.02% and 14.44%, respectively. Conclusion Off-label drug use is common in children in hospitals. The incidence of off-label drug use in hospitalized children is higher than that in outpatient and emergency department, but the types of drugs vary greatly.
作者
段凌志
DUAN Ling-Zhi(Yingkou City Central Hospital,Yingkou 115004,China)
出处
《中国药物经济学》
2019年第10期56-59,63,共5页
China Journal of Pharmaceutical Economics
关键词
超说明书用药
儿科
住院
Off-label drug use
Pediatrics
Hospitalization
