摘要
目的通过分析初次单采血小板捐献者和多次单采血小板捐献者血液检测不合格的原因,为制定针对不同献血经历人群的招募和保留策略提供依据。方法对韶关市中心血站2015年6月1日-2018年6月30日单采血小板捐献者6004人按照初次单采血小板捐献者和多次单采血小板捐献者进行分类,并对他们所献血液的相应血液标本进行传染病4个项目(HBsAg、抗-HCV、抗-HIV和抗-TP)和ALT项目的检测,对血液检测结果进行统计学分析:比较初次与多次单采血小板捐献者比例、初次与多次单采血小板捐献者血液检测不合格结果,对血液检测不合格项目分布情况进行分析。结果单采血小板捐献者血液检验不合格率2015.6.1-2016.6.30、2016.7.1-2017.6.30、2017.7.1-2018.6.30分别为0.60%、0.72%和0.42%(χ^2=15.66,P<0.01);2015.6.1-2018.6.30年,初次单采血小板捐献者和多次单采血小板捐献者血液检验不合格率分别为2.60%和0.28%(χ^2=131.36,P<0.01)。初次单采血小板捐献者和多次单采血小板捐献者占总捐献单采血小板者的比例分别为15.4%、84.6%(χ^2=94.52,P<0.01);2016.7.1-2017.6.30核酸检测不合格率为0.41%(8/1943),是单采血小板捐献者不合格的主要原因。结论初次单采血小板捐献者血液检测不合格项目以HBsAg、抗-HIV为主,有条件的血站可以在初次单采血小板捐献者中开展抗-HIV快速检测。多次血小板捐献者血液检测不合格项目以核酸检测和抗-TP为主,主要由于假阳性结果和后续感染等原因造成。多次单采血小板捐献者血液检测不合格率明显低于初次单采血小板捐献者。
Objective To analyze the causes of unqualified blood test results of new and regular apheresis platelets donors,in order to provide references for developing more effective recruitment and retention strategies.Methods A total of 6004 apheresis platelets donors from June 1,2015 and June 30,2018 in Shaoguan Central Blood Station,were classified into 2 groups,that is first-time and regular donor groups.Screenings of transfusion transmitted diseases(HBsAg,anti-HCV,anti-HIV and anti-TP)and ALT were performed on all specimens and the corresponding detection results were compared between the two groups.Results The unqualified rates of apheresis platelet donors during three time ranges was 0.60%(June 1,2015~June 30,2016),0.72%(July 1,2016 and June 30,2017)and 0.42%(July 1,2017 and June 30,2018)respectively(χ^2=15.66,P<0.01).From June 1,2015 to June 30,2018,the total unqualified rates of new and regular apheresis platelet donors were 2.60%and 0.28%,respectively(χ^2=131.36,P<0.01).The proportion of new and regular apheresis platelet donors in total platelet donors were 15.4%and 84.6%,respectively(χ^2=94.52,P<0.01).In addition,8 out of 1943 donors(0.41%)were screened out by NATs,during July 1,2016 and June 30,2017,which was the main cause of unqualified blood test.Conclusions HBsAg and anti-HIV were the main unqualified items in the blood test of new platelet donors,which suggested that pre-donation rapid tests for HIV may be cost-effective in certain blood centers.Besides,regular donors mainly failed in false positiveties in ELISA methodology or subsequent infections.The regular donor group demonstrates a significantly lower unqualified rate when compared to the other group.
作者
霍宝锋
李慧文
向庆林
胡烨
林奕斌
刘智敏
张天弼
HUO Baofeng;LI Huiwen;XIANG Qinglin;HU Ye;LIN Yibin;LIU Zhimin;ZHANG Tianbi(Shao guan Central Blood Station,Shaoguan,512026,China)
出处
《中国输血杂志》
CAS
2019年第11期1175-1178,共4页
Chinese Journal of Blood Transfusion
关键词
单采
血小板
血液
检测
献血者
归队
apheresis
platelets
blood screening
donors
reentry
