摘要
目的观察锡类散治疗肛周脓肿术后创面愈合的效果。方法选取陕西中医药大学附属医院肛肠科2017年1月至2018年12月收治的92例拟行手术治疗的肛周脓肿患者,按随机数表法将患者分为对照组和观察组各46例。对照组给予常规术后处理,观察组在其基础上加用锡类散治疗。比较两组患者的治疗疗效,创面愈合情况,分泌物、肉芽、红肿评分,以及治疗前后的血清炎性因子水平。结果观察组患者的治疗总有效率为93.48%,明显高于对照组的69.57%,差异有统计学意义(P<0.05);观察组和对照组患者的创面愈合时间[(34.14±3.02)d vs(40.54±4.05)d]、腐肉脱落时间[(4.83±0.42)d vs(5.81±0.61)d]比较,观察组明显少于对照组,创面缩小率为(72.35±7.24)%,明显高于对照组的(58.95±5.89)%,差异均有统计学意义(P<0.05);观察组和对照组患者的红肿评分[(1.34±0.11)分vs(1.57±0.13)分]、肉芽状态评分[(2.14±0.21)分vs(2.58±0.24)分]、分泌物评分[(0.91±0.07)分vs(1.10±0.11)分]比较,观察组明显少于对照组,差异均具有统计学意义(P<0.05);治疗前观察组和对照组患者的白介素-6(IL-6)[(165.03±16.01)ng/mL vs(164.89±15.97)ng/mL]、白介素-8(IL-8)[(0.85±0.21)μg/mL vs(0.92±0.19)μg/mL]、肿瘤坏死因子-α(TNF-α)[(141.58±14.16)ng/m L vs(142.01±14.09)ng/m L]比较差异均无统计学意义(P>0.05);治疗后观察组和对照组患者的IL-6[(95.87±9.59)ng/m L vs(115.12±11.87)ng/m L]、IL-8[(0.43±0.10)μg/m L vs(0.61±0.12)μg/m L]、TNF-α[(98.35±9.08)ng/mL vs(119.82±11.99)ng/mL]比较,观察组明显低于对照组,差异均具有统计学意义(P<0.05)。结论锡类散能有效提高肛周脓肿患者术后创面愈合治疗效果,缩短患者创面愈合时间,改善其创面愈合情况并减轻患者炎症反应,具有临床推广价值。
Objective To observe the effect of tin-like powder on wound healing after perianal abscess surgery.Methods A total of 92 patients with perianal abscess who underwent surgery from January 2017 to February 2018 in the Department of Anorectal Surgery,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine were enrolled.The patients were divided into control group and observation group according to the random number table method(n=46 each).The control group was given routine postoperative treatment,and the observation group was treated with tin-like powder on the basis of the treatment in the control group.The therapeutic efficacy,wound healing,secretion,granulation,redness score,and serum inflammatory factor levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 93.48%,which was significantly higher than69.57%of the control group(P<0.05).The wound healing time and the time of carrion shedding were(34.14±3.02)d and(4.83±0.42)d in the observation group,significantly shorter than(40.54±4.05)d and(5.81±0.61)d in the control group(P<0.05);the wound reduction rate was(72.35±7.24)%,significantly higher than(58.95±5.89)%in the control group(P<0.05);the redness score,the granulation status score,and the secretion score were significantly lower in the observation group than in the control group:(1.34±0.11)points vs(1.57±0.13)points,(2.14±0.21)points vs(2.58±0.24)points,(0.91±0.07)points vs(1.10±0.11)points,P<0.05.Before treatment,there was no statistically significant difference between the two groups in interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α):(165.03±16.01)ng/m L vs(164.89±15.97)ng/mL,(0.85±0.21)μg/mL vs(0.92±0.19)μg/mL,(141.58±14.16)ng/mL vs(142.01±14.09)ng/mL,P>0.05;after treatment,the IL-6,IL-8,TNF-αin the observation group were significantly lower than those in the control group:(95.87±9.59)ng/mL vs(115.12±11.87)ng/mL,(0.43±0.10)μg/mL vs(0.61±0.12)μg/mL,(98.35±9.08)ng/mL vs(119.82±11.99)ng/mL,P<0.05.Conclusion Tin-like powder can effectively improve the healing effect of postoperative wound healing in patients with perianal abscess,shorten the healing time of wounds,improve the healing of wounds,and reduce the inflammatory response of patients.
作者
姜华
岳水娴
JIANG Hua;YUE Shui-xian(Department of Anorectal Surgery,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第23期3050-3052,共3页
Hainan Medical Journal
基金
2017年陕西省自然科学基础研究计划项目(编号:2017JM8166)
关键词
锡类散
肛周脓肿
术后
创面愈合
炎症
Tin-like powder
Perianal abscess
Postoperative
Wound healing
Inflammation
