摘要
目的探讨卵巢癌患者术前血浆纤维蛋白原(FIB)和D-二聚体(D-dimer)水平与预后的关系。方法回顾性分析2008年11月至2012年11月于临颍县人民医院接受卵巢癌手术的126例患者的临床资料,根据ROC曲线,以FIB=365 mg/dL、D-dimer=0.3 mg/L为分界点,将患者分为低FIB组(53例)和高FIB组(73例),低D-dimer组(49例)和高D-dimer组(77例),分析患者术前血浆FIB、D-dimer水平与预后的关系。结果Kaplan-Meier生存分析结果显示,低FIB组和高FIB组总生存时间(OS)分别为(65.28±3.12)、(59.38±1.92)个月,低FIB组OS长于高FIB组,差异有统计学意义(P<0.05)。低D-dimer组和高D-dimer组OS分别为(66.58±3.31)、(59.78±1.91)个月,低D-dimer组OS长于高D-dimer组,差异有统计学意义(P<0.05)。Cox模型分析显示,FIGO分期、病理分级、肿瘤大小、术前血浆FIB水平、术前血浆D-dimer水平是卵巢癌患者OS的独立影响因素(均P<0.05)。结论术前较高的血清FIB和D-dimer水平是卵巢癌患者预后的独立危险因素。
Objective To investigate the relationship between preoperative plasma fibrinogen(FIB)and D-dimer(D-dimer)levels and prognosis in patients with ovarian carcinoma.Methods The clinical data of 126 patients who underwent ovarian carcinoma surgery in Linying County People’s Hospital from November 2008 to November 2012 were retrospectively analyzed.According to the ROC curve,FIB=365 mg/dL and D-dimer=0.3 mg/L were used as the demarcation point.Patients were divided into low FIB group(53 cases)and high FIB group(73 cases),low D-dimer group(49 cases)and high D-dimer group(77 cases).The relationship between preoperative plasma FIB and D-dimer levels and prognosis was analyzed.Results Kaplan-Meier curves showed that the overall survival(OS)of patients in low and high FIB group were(65.28±3.12)and(59.38±1.92)months,respectively.The OS of patients in low FIB group was longer than that of patients in high FIB group,and the difference was statistically significant(P<0.05).The OS of patients in low and high D-dimer group were(66.58±3.31)and(59.78±1.91)months,respectively.The OS of patients in low D-dimer group was longer than that of patients in high D-dimer group,and the difference was statistically significant(P<0.05).Cox model showed that FIGO stage,pathological grade,tumor size,preoperative plasma FIB level,and preoperative plasma D-dimer level were independent influence factors in OS of ovarian carcinoma patients(all P<0.05).Conclusion High preoperative serum FIB and D-dimer levels are independent risk factors for ovarian carcinoma patients.
作者
沈秀华
司国淼
谢娅
SHEN Xiu-hua;SI Guo-miao;XIE Ya(Department of Obstetrics and Gynecology,Linying County People’s Hospital,Luohe 462600,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)
出处
《河南医学研究》
CAS
2019年第23期4234-4237,共4页
Henan Medical Research
基金
国家自然科学基金(81202070)
