摘要
目的探讨使用碘造影剂(ICM)所致药品不良反应(ADR)的特点及相关规律,为其临床合理使用提供参考。方法收集医院2011年至2018年通过网络上报至国家药品不良反应中心的ICM ADR 166例,采用Pareto分析法分析患者年龄及性别、造影目的、造影剂类型、ADR报告类型、ADR累及器官/系统及转归情况等。结果患者年龄41岁以上(76.50%),造影目的为用于增强CT(61.45%),使用碘佛醇注射液(58.43%),ADR类型为已知一般(74.70%),累及皮肤及其附件和消化系统(78.31%),发生ADR后好转(75.30%)等为A类(主要)因素。结论临床医师、药师应了解中成药碘造影剂的ADR和规律,应用时加强监测,确保临床用药安全、有效。
Objective To investigate the characteristics and related rules of adverse drug reactions(ADR)induced by iodinated contrast medium(ICM),and to provide reference for its clinical rational use.Methods Totally 166 cases of ADRs induced by ICM in our hospital and reported to the National Center for Adverse Drug Reaction Monitoring through the internet from 2011 to 2018 were collected.Pareto analysis was used to analyze the age and gender of patients,the purpose of angiography,the type of contrast agent,the type of ADR report,the organ/system involved in ADR and the outcome.Results The age of the patients over 41 years old(76.50%),the purpose of angiography for enhanced-CT(61.45%),the use of Iodofol Injection(58.43%),the type of ADR was known and general(74.70%),the involvement of the skin and its attachments and digestive system(78.31%),and the improvement after the occurrence of ADR(75.30%)were the class A(main)causes.Conclusion Clinicians and pharmacists should understand the rules of ADR induced by Chinese patent medicine iodine contrast agent,strengthen monitoring when using,and ensure the safety and effectiveness of clinical medication.
作者
刘宏明
吴奇华
王建
LIU Hongming;WU Qihua;WANG Jian(Nanchuan People's Hospital of Chongqing Medical University,Chongqing,China 408400)
出处
《中国药业》
CAS
2019年第24期90-92,共3页
China Pharmaceuticals
基金
重庆市南川区科技计划项目[Cx201801]
