摘要
目的分析初诊弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者的心电图特征。方法回顾性收集在天津医科大学附属肿瘤医院病理诊断确诊为DLBCL的90例患者的病例资料,记录抗肿瘤治疗开始前患者临床特征、异常心电图发生率,并手工测量相关基线心电图指标。结果研究人群中位及四分位间距年龄为58(16)岁,其中男53例(58.9%),女37例(41.1%)。既往合并疾病中高血压比例最高(n=25,27.8%),其次是糖尿病(n=13,14.4%)。共54例(60.0%)患者存在基线心电图异常,其中ST-T改变32例(35.6%)最为常见。基线心电图指标统计结果如下:心率(83±17)次/min、P波时限(104.6±11.0)ms、P波振幅(0.13±0.04)m V、V1导联P波终末电势(-0.010±0.011)mm·s、P波离散度(37.0±10.1)ms、PR间期(149±23)ms、QRS时限(89.3±16.4)ms、QRS电轴46.0°±35.1°、校正QT间期(417.6±61.5)ms、QT离散度(43±16)ms、T波波峰至T波终点时限(86±21)ms、心脏电生理平衡指数4.0±0.8。结论初诊DLBCL患者合并心血管疾病患病率高,半数以上患者合并心电图异常,心电图指标相对正常,临床上应高度关注。
Objective To analyze electrocardiographic characteristics of patients with diffuse large B-cell lymphoma(DLBCL).Methods Electronic medical records of 90 patients who were pathologically diagnosed as DLBCL were retrospectively reviewed in Tianjin Medical University Cancer Institute and Hospital between December2014 and September 2015.Clinical characteristics,incidence of abnormal electrocardiogram(ECG)and manually measured baseline hypertension electrocardiographic parameters were collected into the study.Results The mean age of the cohort was 58 years old,among which 53 cases(58.9%)were males.In these patients,25 cases(27.8%)had a history of hypertension and 13 cases(14.4%)had a history of diabetes mellitus.Abnormal baseline ECG were discovered in 54 cases(60.0%),among which 32 cases(35.6%)showed ST-T change.The statistical results of baseline electrocardiographic are as follows:HR(83±17)beat/min,PWD(104.6±11.0)ms,PWA(0.13±0.04)m V,Ptf V1(-0.010±0.011)mm·s,Pd(37.0±10.1)ms,PRI(149±23)ms,QRSD(89.3±16.4)ms,QRS axis 46.0°±35.1°,QTc(417.6±61.5)ms,QTd(43±16)ms,Tp Te(86±21)ms、i CEB 4.0±0.8.Conclusion The newly diagnosed DLBCL patients have a high morbidity of cardiovascular diseases,and more than 50%patients are combined with abnormal baseline ECG,with relatively normal electrocardiographic parameters,which should be highly concerned in clinical practice.
作者
陈子良
卢可
周玲玲
刘岱麒
李秀莲
韩雪
张会来
刘彤
Chen Zi-liang;Lu Ke;Zhou Ling-ling;Liu Dai-qi;Li Xiu-lian;Han Xue;Zhang Hui-lai;Liu Tong(Department of Cardiology,The Second Hospital of Tianjin Medical University,Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease,Tianjin Institute of Cardiology,Tianjin 300211;Department of Lymphoma,Tianjin Medical University Cancer Institute and Hospital,The Sino-US Center for Diagnosis and Treatment on Lymphoma and Leukemia,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China)
出处
《实用心电学杂志》
2019年第6期410-413,共4页
Journal of Practical Electrocardiology
基金
国家自然科学基金资助项目(81970270)
