摘要
以双甘油硼酸酯为原料,采用催化氧化法制备了双甘油酸硼酸酯中间体,再使中间体与邻苯二胺或乙二胺或其衍生物进行酰胺化-环化反应,高效合成了5种标题化合物,并用IR、UV、1HNMR、13CNMR和元素分析仪表征了产物结构;采用正交试验法,优化了新化合物的合成反应条件;结果表明,影响合成的因素次序为:原料物质的量比>环化温度>酰化时间>环化时间;实验为工业地沟油水解副产物甘油的综合利用提供了新技术方法。
Bis(glyceric acid)borate intermediates were prepared by catalytic oxidation from diglycerol borate.Five kinds of title compounds were synthesized efficiently by one-pot amidation-cyclization reaction of bis(glyceric acid)borate and o-phenylendiamine or ethylenediamine or their derivatives in xylene medium respectively.The structure was confirmed by IR,UV,1HNMR,13CNMR and organic elemental analyzer.The reaction conditions were optimized by orthogonal test.The order of the factors influencing the synthesis was as follows:the mass ratio of raw materials>the cycling reaction temperature>the acylation reaction time>the cycling reaction time.It provides a new technical method for the comprehensive utilization of glycerol,a by-product of the hydrolysis of industrial gutter oil.
作者
贾群坡
袁斌
吕松
朱素芳
JIA Qun-po;YUAN Bin;LV Song;ZHU Su-fang(Faculty of Environmental Science and Engineering,Guangdong University of Technology,Guangzhou 510006,China;Foshan Environmental Monitoring Center Station,Foshan 528000,China)
出处
《化学试剂》
CAS
北大核心
2019年第12期1322-1326,共5页
Chemical Reagents
基金
广东省科技计划资助项目(2016A020221035)
关键词
咪唑衍生物
甘油酸
硼酸酯
合成
表征
imidazole derivatives
glyceric acid
borate
synthesis
characterization
