摘要
目的:探讨多囊卵巢综合征(PCOS)患者的中医证型分布规律及其与临床特征的相关性。方法:由临床科研一体化系统纳入的1059例PCOS患者进行中医辨证,比较各证型中PCOS患者临床特征异常的发生率,并分析其与证型相关性。结果:①1059例PCOS患者分为脾虚痰湿证,肾虚肝郁证,肾虚血瘀证和痰瘀互结证,所占比例分别为41.45%,28.99%,10.29%和19.26%;②脾虚痰湿证和痰瘀互结证PCOS患者发病年龄主要以>30岁为主,临床特征以腰围、WHR、AND、FPG、FINS、HOMA-IR、TG、TC和LDL水平升高,黑棘皮发生率升高,SHBG和HDL水平下降等为主;肾虚肝郁证和肾虚血瘀证PCOS患者发病年龄主要以20~30岁为主,临床表现以LH/FSH比值升高为主;③脾虚痰湿证与黑棘皮、FPG、HOMA-IR、TC和LDL呈正相关,与多毛、痤疮和HDL呈负相关;肾虚肝郁证与TC和HDL呈正相关,与FPG、FINS、HOMA-IR和TG呈负相关;肾虚血瘀证与痤疮、黑棘皮和HOMA-IR呈正相关,与FINS和TC呈负相关;痰瘀互结证与腰围、多毛、T、FPG、FINS、HOMA-IR、TG、TC和LDL呈正相关,与LH、PRL和SHBG呈负相关。结论:不同中医证型的PCOS患者具有不同的临床特征表现,且各证型与临床特征之间存在一定的相关性。
Objective:To investigate the distribution of TCM syndromes in patients with polycystic ovary syndrome(PCOS)and its correlation with clinical features.Methods:Totally 1059 patients with PCOS from integrated clinical research system were treated with TCM syndrome differentiation.Then we compared the incidence of abnormal clinical characteristics of PCOS patients in each syndrome,and its correlation with syndrome type was analyzed.Results:(1)All 1059 PCOS patients were divided into spleen deficiency and phlegm-damp,kidney deficiency and liver depression,kidney deficiency and blood stasis and binding of phlegm and stasis syndromes,accounting for 41.45%,28.99%,10.29%and 19.26%respectively.(2)The onset age of PCOS patients with spleen deficiency and phlegm-damp and binding of phlegm and stasis syndrome were mainly over 30 years oldand their clinical characteristics were waist circumference,WHR,AND,FPG,FINS,HOMA-IR,TG,TC and LDL levels increased.The incidence of acanthosis nigricans increased,SHBG and HDL levels decreased.PCOS patients with kidney deficiency and liver depression and kidney deficiency and blood stasis syndromes were mainly 20~30 years old.The clinical manifestations of LH/FSH ratio increased.(3)Spleen deficiency and phlegm-damp was positively correlated with acanthosis nigricans,FPG,HOMA-IR,TC and LDL,and negatively correlated with hair,acne and HDL.Kidney deficiency and liver depression was positively correlated with TC and HDL,and negatively correlated with FPG,FINS,HOMA-IR and TG.Kidney deficiency and blood stasis was positively correlated with acne,acanthosis nigricans and HOMA-IR,and negatively correlated with FINS and TC.Binding of phlegm and stasis was positively correlated with waist circumference,hirsutism,T,FPG,FINS,HOMA-IR,TG,TC and LDL,and negatively correlated with LH,PRL and SHBG.Conclusion:PCOS patients with different TCM syndromes have different clinical characteristics,and there is a certain correlation among each syndromes and clinical characteristics.
作者
张红阳
侯丽辉
李妍
ZHANG Hongyang;HOU Lihui;LI Yan(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;Departmnet of Obstetric and Gynecology,The First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《辽宁中医杂志》
CAS
2019年第11期2357-2360,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金项目(81804139)
国家中医药管理局中医临床研究基地业务建设科研专项课题(JDZX2015058)
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2012039)
国家中医药管理局全国名老中医药专家传承工作室建设项目(2014-9-10)
关键词
多囊卵巢综合征
中医证型
LOGISTIC回归分析
polycystic ovary syndrome
traditional Chinese medical syndrome
Logistic regression analysis
