摘要
目的研究非小细胞肺癌(NSCLC)患者凝血功能变化及其与TNM分期的相关性。方法选择我院120例NSCLC患者作为NSCLC组,选择我院同期收治的45例健康体检者作为健康组,检测及比较两组凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、D二聚体(D-D)]水平,并分析其与TNM分期的相关性。结果 NSCLC组Fbg、D-D水平显著高于健康组(P<0.05),PT、aPTT、TT与健康组比较差异无统计学意义(P>0.05);临床分期Ⅲ、Ⅳ期患者Fbg、D-D水平显著高于Ⅰ、Ⅱ期患者(P<0.05),PT、aPTT、TT与Ⅰ、Ⅱ期患者比较差异无显著性(P>0.05);Spearman相关系数分析显示,NSCLC组Fbg、D-D水平与患者TNM分期呈正相关(P<0.05)。结论 NSCLC患者Fbg、D-D水平升高,其表达水平与患者TNM分期有关,检测其变化有助于评估患者预后。
Objective To study the changes of coagulation function in patients with non-small cell lung cancer(NSCLC)and its correlation with TNM stage.Methods 120 patients with NSCLC in our hospital were selected as NSCLC group and 45 healthy subjects treated in our hospital at the same time as healthy group.The levels of two groups of clotting functions(PT,aPTT,TT),Fibrinogen(Fbg),D-dimer(D-D)were detected and analyzed with TNM staging.Results The level of Fbg and D-D in NSCLC group was significantly higher than that of healthy group(P<0.05),and the level of Fbg and D-D in clinical stage III and IV patients was significantly higher than that of patients in clinical stage Ⅰand Ⅱ(P<0.05).Spearman correlation coefficient analysis showed that FIB and DD levels in NSCLC group were positively correlated with TNM stage(P<0.05),PT,TT,aPTT. There was no correlation with TNM stage(P>0.05).Conclusion The level of Fbg,D-D in patients with NSCLC is increased,and its expression level is related to the stage of TNM.Detection of the changes is helpful to evaluate the prognosis of patients with NSCLC.
作者
王鑫
王环
胡佐宇
WANG Xin;WANG Huan;HU zuo-yu(Department of Respiratory Medicine,The People's Hospital of Kaizhou District,Chongqing,405400,China;Department of General Surgery,The People’s Hospital of Zhidan County,yan’an,717500,China)
出处
《血栓与止血学》
2019年第6期944-946,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
凝血功能
TNM分期
非小细胞肺癌
Coagulation,function
TNM,stages
Non-small,cell lung cancer
