摘要
目的:分析血浆心肌营养素-1(CT-1)、促生长激素释放多肽(Ghrelin)、脂蛋白相关性磷脂酶A2(Lp-PLA2)在冠心病中的临床价值。方法:选择我院2015年3月至2018年6月心内科收治的176例住院患者,其中43例对照组,45例稳定型心绞痛(SAP),42例不稳定型心绞痛(UAP),46例急性心肌梗死(AMI)。比较各组血浆CT-1、Ghrelin、Lp-PLA2水平,左室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV),并分析之间的相关性、和心血管不良事件(MACE)的关系。结果:AMI组血浆CT-1、Lp-PLA2水平、LVEDV及LVESV依次高于UAP组、SAP组、对照组,AMI组血浆Ghrelin、LVEF依次低于UAP组、SAP组、对照组,比较有统计学差异(P<0.05)。血浆CT、Lp-PLA2水平和LVEF均呈负相关,(r分别=-0.786、-0.654,P<0.05),和LVEDV、LVESV均呈正相关,(r分别=0.881、0.702,0.621,0.514,P<0.05);血浆Ghrelin水平和LVEF呈正相关(r=0.620,P<0.05),和LVEDV、LVESV均呈负相关,(r分别=-0.433,0.-594,P<0.05)。有MACE组血浆CT-1、Lp-PLA2水平高于无MACE组,血浆Ghrelin低于无MACE组(P<0.05)。CT-1、Ghrelin、Lp-PLA2、CT-1+Ghrelin +Lp-PLA2对MACE预测的曲线下面积分别为0.816、0.797、0.699,CT-1+Ghrelin +Lp-PLA2曲线下面积大于单个指标。经多因素Logistic回归分析可见,血浆CT-1、Lp-PLA2水平为冠心病患者不良心脏事件发生的独立危险因素,Ghrelin为保护因素。结论:血浆CT-1、Ghrelin、Lp-PLA2和冠心病有关,其水平变化可能能够提示心血管不良事件。
To analysis of clinical value of plasma cardiotrophin -1(CT-1), growth hormone releasing polypeptide (Ghrelin), lipoprotein-associated phospholipase A2(Lp-PLA2) in coronary heart disease. Methods: 176 cases of coronary heart disease was from March 2015 to June 2018, 43 cases of control group, 45 stable angina pectoris (SAP), 42 cases of unstable angina pectoris (UAP), 46 cases of acute myocardial infarction (AMI). Comparison between groups of plasma CT-1, Ghrelin, Lp-PLA2 level, left ventricular ejection fraction (LVEF), left ventricular end systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV),and analyze the correlation between them, and the relationship between cardiac adverse events. Results: plasma CT-1,Lp-PLA2 levels, LVEDV and LVESV of AMI group was higher than the UAP group, SAP group, control group, plasma Ghrelin of AMI group was lower than the UAP group, SAP group, control group, there was statistically significant differences (P<0.05). Plasma CT, Lp-PLA2 level and LVEF was negatively correlated, (r=-0.786, -0.654, P<0.05), and both LVEDV and LVESV was positively correlated, (r=0.881, 0.702, 0.621, 0.514, P<0.05). plasma Ghrelin level and LVEF was positively correlated (r=0.620, P<0.05), and LVEDV, LVESV were negatively correlated, (r=-0.433, 0.-594, P<0.05). Plasma CT-1 and Lp-PLA2 levels in MACE group were higher than those in non-MACE group, and plasma Ghrelin was lower than that in non-MACE group (P<0.05). The areas under the curve predicted by CT-1, Ghrelin, Lp-PLA2, CT-1+Ghrelin +Lp-PLA2 for MACE were 0.816, 0.797 and 0.699, and the areas under the curve of CT-1+Ghrelin +Lp-PLA2 were larger than a single index. Multifactorial Logistic regression analysis shows, plasma levels of CT-1 and Lp-PLA2 was independent risk factors for adverse cardiac events in patients with coronary heart disease, Ghrelin was a protective factor. Conclusion: Plasma CT-1, Ghrelin, Lp-PLA2 are related to coronary heart disease, and their changes may indicate adverse cardiovascular events.
作者
刘洋
廖博
魏继棠
LIU Yang(Laboratory department, the Fifth People's Hospital of Qinghai, Qinghai Xining 810007, China)
出处
《河北医学》
CAS
2019年第12期2108-2112,共5页
Hebei Medicine
基金
青海省自然科学基金项目,(编号:20130226)
关键词
冠心病
心肌营养素-1
促生长激素释放多肽
脂蛋白相关性磷脂酶A2
Coronary heart disease
Cardiotrophin-1
Growth hormone releasing peptide
Lipoprotein correlation phospholipase A2
