摘要
由于人类的心脏缺乏自我修复的能力,故心肌梗死等损伤后心肌细胞的丢失可导致心力衰竭和死亡。因此,努力提高心肌细胞自我修复能力是具有前景的治疗策略。Hippo通路作为器官大小和生长的调节因子,是一种进化和功能上十分保守的通路,其在细胞增殖、凋亡和分化中起重要作用。靶向Hippo通路可为心肌梗死后心肌的修复和再生提供新的治疗思路。此篇综述总结了近十年的发现,揭示Hippo通路在心脏发育、再生和疾病中的作用,并探讨其在心脏疾病诊断和治疗中的可能策略。
The human heart lacks the ability to repair itself,so the loss of myocardial cells after injury such as myocardial infarction can lead to heart failure and death.Therefore,improving cardiomyocyte viability remain attractive therapeutic strategies.Hippo pathway,as a regulator of organ size and growth,is an evolutionarily and functionally conservative pathway,which plays an important role in cell proliferation,apoptosis and differentiation.Targeting the Hippo pathway provides a new therapeutic approach for cardiac repair and regeneration for myocardial infarction.In this review,we summarize the findings of the past decade,reveal the role of Hippo pathway in heart development,regeneration and disease,and explore its possible strategies in the diagnosis and treatment of heart disease.
作者
常文婧
王丽娜
CHANG Wenjin;WANG Lina(Department of Pathophysiology,Basic School of Medicine,Harbin Medical University,Harbin 150086,Heilongjiang,China)
出处
《心血管病学进展》
CAS
2019年第8期1115-1118,共4页
Advances in Cardiovascular Diseases
基金
黑龙江省自然科学基金(H2016015)
关键词
Hippo通路
心脏发育
再生
心肌梗死
Hippo pathway
Heart development
Regeneration
Myocardial infarction
