摘要
目的观察来曲唑治疗乳腺癌的疗效及对患者子宫内膜的影响。方法选取2016年1月~2018年12月我院收治绝经后乳腺癌患者60例,随机均分为两组。观察组口服来曲唑片,对照组口服枸橼酸他莫昔芬片,两组均连续用药3个月。比较两组疗效,观察患者血清肿瘤标记物[癌胚抗原(CEA)、糖类抗原125(CA125)、糖链抗原15-3(CA15-3)]水平变化,对比两组治疗后子宫内膜厚度及子宫内膜活检阴性率。结果观察组总有效率为86.67%高于对照组的63.33%,差异有统计学意义(P<0.05)。治疗后两组CEA、CA125、CA15-3水平较治疗前降低(P<0.05),且治疗后观察组CEA、CA125、CA15-3水平(4.37±1.16)ng/mL、(12.03±2.65)U/mL、(12.39±3.13)U/mL明显低于对照组(5.04±1.84)ng/mL、(13.47±3.18)U/mL、(14.11±3.27)U/mL(P<0.05)。治疗后子宫内膜厚度观察组(5.84±0.74)mm低于对照组(6.42±1.01)mm(P<0.05)。治疗后子宫内膜活检阴性率观察组为100%,与对照组90%比较,差异无统计学意义(P>0.05)。结论来曲唑治疗绝经后乳腺癌效果良好,可有效降低患者血清肿瘤标记物水平,改善子宫内膜厚度。
Objective To observe curative effects of letrozole in treatment of breast cancer and its effect on endometrium of patients.Methods 60 patients with breast cancer after menopause who were admitted and treated in our hospital from January 2016 to December 2018 were selected and they were randomly divided into two groups.The observation group was given oral letrozole tablets while the control group was given oral tamoxifen citrate tablets.Both groups were continuously treated for 3 months.The curative effects of the two groups were compared.The changes of serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and sugar chain antigen 15-3(CA15-3)]of patients were observed.The endometrial thickness and the negative rate of endometrial biopsy were compared between the two groups.Results The total effective rate of the observation group(86.67%)was higher than that of the control group(63.33%)(P<0.05).The levels of CEA,CA125 and CA15-3 in the two groups were lower than those before treatment(P<0.05).The levels of CEA,CA125 and CA15-3 in the observation group after treatment were(4.37±1.16)ng/mL,(12.03±2.65)U/mL,(12.39±3.13)U/mL,significantly lower than those in the control group(5.04±1.84)ng/mL,(13.47±3.18)U/mL,(14.11±3.27)U/mL(P<0.05).After treatment,the endometrial thickness un the observation group(5.84±0.74)mm was lower than that in the control group(6.42±1.01)mm(P<0.05).There was no significant difference between the observation group(100%)and the control group(90%)in the negative rate of endometrial biopsy after treatment(P>0.05).Conclusion Letrozole is effective in the treatment of postmenopausal breast cancer,which can effectively reduce serum tumor marker levels and improve endometrial thickness.
作者
杨锭洪
林长裕
黄晓龙
YANG Dinghong;LIN Changyu;HUANG Xiaolong(Puning People’s Hospital,Puning 515300,China)
出处
《中国医药科学》
2019年第22期225-227,247,共4页
China Medicine And Pharmacy
