摘要
轻度认知障碍是介于正常衰老和痴呆之间的一种中间状态,是发展为阿尔茨海默病的高危因素,其特征是记忆衰退比正常衰老更快。近年来,随着神经影像学的迅速发展,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)、扩散张量成像(diffusion tensor imaging,DTI)逐渐应用于轻度认知障碍的早期诊断,在展现出各自优势的同时,又表现出一些不足。因此,人们尝试将它们联合起来进行分析,其基本分为3种方法:rs-fMRI辅助DTI、DTI辅助rs-fMRI及rs-fMRI和DTI的等位联合,从而获得了更高的诊断效能。笔者将从上述3种方法分别在轻度认知障碍中的联合应用进行阐述。
Mild cognitive impairment,an intermediate state between normal aging and dementia,is a risk factor for developing Alzheimer’s disease and is characterized by memory loss faster than normal aging.In recent years,along with the rapid development of neuroimaging,resting-state functional magnetic resonance imaging(rs-fMRI)and diffusion tensor imaging(DTI)are gradually applied to the early diagnosis of mild cognitive impairment,showing their respective strengths and weaknesses.Therefore,people try to combine them for analysis,which can be basically divided into three methods:rs-fMRI-assisted DTI,DTI-assisted rs-fMRI and rs-fMRI and DTI allelic combination,thus obtaining higher diagnostic efficiency.The author will expound the combined application of the above three methods in mild cognitive impairment.
作者
李杨曈
王蓝博
孙洪赞
LI Yangtong;WANG Lanbo;SUN Hongzan(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《磁共振成像》
CAS
2019年第12期933-936,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
2017年辽宁省重点研发计划指导计划基金项目(编号：2017225012)~~
关键词
认知障碍
功能磁共振成像
扩散张量成像
磁共振成像
cognition disorders
functional magnetic resonance imaging
diffusion tensor imaging
magnetic resonance imaging
