摘要
目的了解目前微小RNA(miRNA)在三阴性乳腺癌(TNBC)发病机制中的作用,以期为TNBC的发病机制了解及其治疗提供参考。方法对近几年国内外有关TNBC与miRNA研究进展的相关文献进行综述。结果 miRNA可以通过抑制或促进靶基因表达并参与包括细胞的增殖、凋亡、自噬、分化、转移等多种生物过程,其也可以通过上皮-间充质转化参与调节TNBC进展,与乳腺癌的诊断、预后和治疗有关。结论 TNBC作为预后差、复发转移率和死亡率均高的乳腺癌高侵袭性临床亚型,miRNA在其发病中十分重要,其成为TNBC潜在的治疗靶点,然而想要将其运用到临床中还有许多问题尚未解决,但是研究miRNA在TNBC中的机制对于其治疗、预防等有一定的必要性。
Objective To understand current research progress of microRNA(miRNA) in pathogenesis of triple-negative breast cancer(TNBC), and to provide reference for understanding pathogenesis and treatment of TNBC. Method The research progress of relationship of TNBC and miRNA was reviewed by reading relevant literatures at home and abroad in recent years. Results The miRNAs were involved in a variety of biological processes, including the cell proliferation,apoptosis, autophagy, differentiation, metastasis, etc., and played an important role in the cancer initiation and metastasis.Therefore, researchers had attempted to treat and prevent the TNBC by targeting miRNAs. At present, there had been a large number of reports that the miRNAs played a key role in TNBC, which were classified as the anti-oncogene and oncogene, and was associated with metastasis and prognosis of TNBC. Conclusion miRNA is very important in pathogenesis of TNBC. Mechanism of studying miRNA is necessary for treatment and prevention of TNBC.
作者
刘欢
李红昌
陈亚峰
高磊
李劼
奉典旭
LIU Huan;LI Hongchang;CHEN Yafeng;GAO Lei;LI Jie;FENG Dianxu(Department of General Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,P.R.China;Department of General Surgery,Minhang District Central Hospital,Shanghai 201100,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2020年第1期103-106,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金项目(项目编号：81703881)
上海市普陀区临床重点专科(甲乳专科)(项目编号：2016101A)
关键词
三阴性乳腺癌
微小RNA
上皮-间充质转化
triple negative breast cancer
microRNA
epithelial-mesenchymal transition
