摘要
目的研究复方阿嗪米特肠溶片联合多酶片治疗功能性消化不良的效果。方法选择2016年1月-2018年12月泰州市第三人民医院收治的60例功能性消化不良患者,随机分为两组,每组各30例。对照组患者口服多酶片,3片/次,3次/d。观察组在对照组的基础上加服复方阿嗪米特肠溶片,10 mg/次,3次/d。两组患者均治疗1个月。比较两组的临床治疗效果,症状改善情况和胃肠激素水平。结果治疗后,观察组的有效率为93.33%,明显高于对照组的70.00%(P<0.05)。治疗后,两组餐后饱胀、嗳气、上腹痛以及上腹部烧灼感评分均明显降低(P<0.05),且观察组症状评分明显更低(P<0.05)。治疗后,两组的胃动素(MTL)和神经肽Y(NPY)水平明显升高,血管活性肽(VIP)水平均明显降低(P<0.05),且观察组胃肠激素水平明显优于对照组(P<0.05)。两组腹胀、腹泻、呕吐和头晕的发生率无明显的差异(P>0.05)。结论复方阿嗪米特肠溶片联合多酶片能更为显著地改善功能性消化不良的症状,提高疗效,调节胃肠激素水平。
Objective To study the effect of Compound Azintamide Enteric-coated Tablets combined with Multienzyme Tablets in treatment of functional dyspepsia. Methods Selected 60 cases of patients with functional dyspepsia who were treated in Taizhou Third People’s Hospital from January 2016 to December 2018, and divided into two groups randomly, each group had 30 cases. The control group was treated with Multienzyme Tablets, 3 tablets/time, three times daily. While the observation group was treated with Compound Azintamide Enteric-coated Tablets on the basis of control group, 10 mg/time, three times daily. Patients in two groups were treated for 1 month. The clinical effects, symptom improvement and gastrointestinal hormone levels of two groups were compared. Results After treatment, the effective rate of the observation group was 93.33%, which was significantly higher than70.00% in the control group(P < 0.05). After treatment, the scores of postprandial fullness, belching, upper abdominal pain and burning sensation of upper abdomen in both two groups were significantly decreased(P < 0.05), and those in the observation group were significantly lower(P < 0.05). After treatment, the levels of MTL and NPY in two groups were significantly increased, and the levels of VIP were significantly decreased(P < 0.05), and the gastrointestinal hormone levels in the observation group were significantly better than those in the control group(P<0.05). There was no significant difference in the incidence of abdominal distension, diarrhea, vomiting and dizziness between the two groups(P > 0.05). Conclusion Compound Azintamide Enteric-coated Tablets combined with Multienzyme Tablets can more significantly improve the symptoms of functional dyspepsia and the clinical effect, regulate the level of gastrointestinal hormone.
作者
杨洁
李晶
丁霞
卢晨霞
YANG Jie;LI Jing;DING Xia;LU Chenxia(Department of Pharmacy,Taizhou Third People's Hospital,Taizhou 225321,China;Department of Gastroenterology,Taizhou Third People's Hospital,Taizhou 225321,China)
出处
《药物评价研究》
CAS
2019年第12期2406-2409,共4页
Drug Evaluation Research
基金
江苏省科技计划项目(BE2017605)
