摘要
目的:探讨三种促排卵方案联合宫腔内人工授精(IUI)治疗多囊卵巢综合征所致不孕临床效果。方法:选定2017年1月-2019年1月泉州市妇幼保健院收治的多囊卵巢综合征所致不孕患者120例进行研究。按照随机数字表法将其分为A、B、C组,各40例,分别采用不同排卵方案联合IUI治疗。A组采用克罗米芬(CC),B组采用人绝经期促性腺激素(HMG),C组采用CC联合HMG。比较三组注射人绒毛膜促性腺激素(hCG)日的生殖激素水平[黄体生成素(LH)、雌二醇(E2)、血清睾酮(T)]、成熟卵泡数及子宫内膜厚度、妊娠率、流产率、重度卵巢过度刺激综合征(OHSS)及子宫动脉及卵巢动脉血流参数[峰值血流速度(PSV)、阻力指数(RI)]。结果:B组hGG注射日E2、LH水平高于C组,且C组高于A组(P<0.05)。三组T水平比较差异均无统计学意义(P>0.05)。B组成熟卵泡数明显多于A、C组(P<0.05)。A组子宫内膜厚度低于B、C组(P<0.05)。B、C组患者临床妊娠率及排卵率明显高于A组,差异有统计学意义(P<0.05),但B组和C组排卵率及妊娠率比较,差异无统计学意义(P>0.05)。B组OHSS发生率明显高于A、C组,差异有统计学意义(P<0.05),但A、C两组比较差异无统计学意义(P>0.05)。C组自然流产率明显低于A、B组,差异有统计学意义(P<0.05),但A、B两组比较差异无统计学意义(P>0.05)。三组PSV和RI比较差异均无统计学意义(P>0.05)。结论:采用CC联合HMG联合IUI治疗多囊卵巢综合征不孕具有更好的效果,积极改善卵巢病情,在减少HMG剂量的同时改善子宫内膜厚度,降低流产率。
Objective:To investigate the clinical efficacy of three ovulation induction schemes combined with intrauterine artificial insemination(IUI)in the treatment of infertility caused by polycystic ovary syndrome.Method:A total of 120 cases of infertility caused by polycystic ovary syndrome admitted in Quanzhou Maternal and Child Health Hospital from January 2017 to January 2019 were selected for the study.According to the random number table method,they were divided into group A,group B and group C,40 cases in each group,and were treated with different ovulation schemes combined with IUI.Group A was treated with Clomiphene Citrate(CC),group B was treated with Human Menopausal Gonadotropin(HMG),and group C was treated with CC combined with HMG.The reproductive hormone levels of human chorionic gonadotropin(hCG)injections[Luteinizing hormone(LH),estradiol(E2),serum testosterone(T)],mature follicle count and endometrial thickness,pregnancy rate,abortion rate,severe ovarian hyperstimulation syndrome(OHSS),and uterine artery and ovarian arterial blood flow parameters[peak blood flow velocity(PSV),resistance index(RI)]were compared among the three groups.Result:The levels of E2 and LH in group B were higher than those in group C,and those in group C were higher than those in group A(P<0.05).There was no significant difference in T level among the three groups(P>0.05).The number of mature follicles in group B was significantly higher than that in group A and C(P<0.05).The thickness of endometrium in group A was lower than that in group B and C(P<0.05).The clinical pregnancy rate and ovulation rate in group B and C were significantly higher than that in group A,the differences were statistically significant(P<0.05),but there were no statistically significant differences in ovulation rate and pregnancy rate between group B and group C(P>0.05).The incidence of OHSS in group B was significantly higher than that in group A and C,the differences were statistically significant(P<0.05),but there was no statistically significant difference between groups A and C(P>0.05).The rate of spontaneous abortion in group C was significantly lower than that in group A and B,the differences were statistically significant(P<0.05),but there was no statistically significant difference between groups A and B(P>0.05).There was no significant difference in PSV and RI between the three groups(P>0.05).Conclusion:CC combined with HMG and IUI in the treatment of polycystic ovary syndrome infertility has a better effect,actively improve ovarian disease,reduce the dose of HMG and improve endometrial thickness,and reduce abortion rate.
作者
陈小莉
吴东旭
王育梅
谢辉奕
郭一彪
朱华芳
姚建凤
吴培雅
郑文为
CHEN Xiaoli;WU Dongxu;WANG Yumei;XIE Huiyi;GUO Yibiao;ZHU Huafang;YAO Jianfeng;WU Peiya;ZHENG Wenwei(nsemination Ovulation rate Pregnancy rate Quanzhou Maternal and Child Health Hospital,Quanzhou 362000,China)
出处
《中外医学研究》
2019年第35期7-10,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
多囊卵巢综合征
不孕
促排卵方案
人工授精
排卵率
妊娠率
Polycystic ovary syndrome
Infertility
Ovulation induction schemes
Intrauterine artificial insemination
Ovulation rate
Pregnancy rate
