摘要
目的 分析氟康唑眼水滴耳治疗霉菌性外耳道炎的临床效果及对复发率、炎症因子的影响.方法 选择2017年3月至2018年7月在本院诊断且符合纳入标准的100例霉菌性外耳道炎患者为观察对象,采用随机数字表法将其分为观察组和对照组,每组各50例.观察组采用氟康唑眼水滴耳治疗,对照组采用达克宁软膏涂耳治疗.比较两组患者临床疗效、炎症因子[肿瘤坏死因子(TNF)-α、白细胞介素(IL)-4、IL-6]水平、复发率及不良反应发生率.结果 观察组总有效率显著高于对照组(P<0.05);治疗后,两组患者炎症因子水平(TNF-α、IL-4及IL-6)均显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05);治疗后,观察组复发率显著低于对照组(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05).结论 氟康唑眼水滴耳治疗霉菌性外耳道炎的临床效果优于达克宁软膏涂耳,而且能有效降低患者炎症反应及复发率,且具有较好的用药安全性.
Objective To analyze the clinical efficacy,recurrence rate and inflammatory factors levels of fluconazole treatments of fungal otitis externa.Methods A total of 100 patients with fungal otitis externa who were treated in our hospital were selected from Mar.2017 and Jul.2018,and they were divided into observation group(n=50)and control group(n=50)according to the random number table method.The observation group received fluconazole treatment,the control group received miconazole nitrate cream treatment.The clinical efficacy,inflammatory factors levels(tumor necrosis factor(TNF)—α,interleukin(IL)—4 and IL—6),recurrence rate and adverse reaction rate were compared between the two groups.Results The total effective rate of observation group was significantly higher than that in control group(P<0.05).After treatment,the levels of TNF—α,IL—4 and IL—6 in the two groups were significantly decreased(P<0.05),and the levels of TNF—α,IL—4 and IL—6 in observation group were obviously lower than those in control group(P<0.05).After treatment,the recurrence rate in observation group were also lower than those in control group(P<0.05)and there was no significant differences in adverse reaction rate between the two groups(P>0.05).Conclusion Fluconazole can not only improve the clinical efficacy,but also decrease the inflammatory response,recurrence rate and has a good safety,which has a better effect on patients with fungal otitis externa than miconazole nitrate cream.
出处
《浙江临床医学》
2019年第12期1681-1682,共2页
Zhejiang Clinical Medical Journal
