摘要
[目的]探讨四逆散联合帕罗西汀治疗抑郁症的临床效果。[方法]将就诊于周口市中医院80例抑郁症患者分为两组,对照组40例,帕罗西汀片;治疗组40例,服用四逆散联合帕罗西汀片。所用患者连续进行8周临床治疗,比较汉密顿抑郁量表(HAMD)和抑郁自评量表(SDS)评分,5-羟色胺和皮质醇水平变化。[结果]临床治疗8周后,治疗组HAMD和SDS两项评分明显低于对照组评分,存在显著差异(P<0.05)。5-羟色胺和皮质醇含量测定结果显示患者药物治疗后5-羟色胺水平显著升高(P<0.05)而皮质醇水平显著降低(P<0.05),治疗组和对照组比较也存在显著差异。另外临床观察结果显示治疗组不良发生率显著低于对照组。[结论]四逆散联合帕罗西汀片可以显著增加患者体内5-羟色胺水平,降低皮质醇水平,在临床上有很好的临床治疗效果,为治疗抑郁症提供了新的方案,值得在临床中广泛应用。
[Objective] To investigate the clinical effect of Sini Powder combined with paroxetine in the treatment of depression by regulating the content of 5-hydroxytryptamine and cortisol. [Methods] Eighty patients with depression admitted to Zhoukou Hospital of Traditional Chinese Medicine from 2015 to 2018 were divided into two groups. Forty patients in the control group were treated with paroxetine tablets. Forty patients in the treatment group were treated with Sini Powder combined with paroxetine tablets. The patients were treated for 8 consecutive weeks. The HAMD and SDS scores were measured and compared,and the changes in 5-hydroxytryptamine and cortisol levels were measured. [Results]After 8 weeks clinical treatment,HAMD and SDS scores in the treatment group were significantly lower than those in the control group with significant differences( P <0.05). The measurement results of 5-hydroxytryptamine and cortisol showed that 5-hydroxytryptamine levels were significantly increased(P<0.05) and cortisol levels were significantly decreased(P<0.05) after drug treatment,and there were significant differences between two groups. In addition,the clinical observation results showed that the incidence of adverse events in the treatment group was significantly lower than that in the control group. [Conclusion] The combination of Sini Powder and paroxetine tablets can significantly increase the level of 5-hydroxytryptamine and reduce the level of cortisol in patients,which has a good clinical effect and provides a new treatment for depression,and is worthy of wide application in clinical practice.
作者
吴利利
孟辉
吴阿莉
彭威风
苏庆华
李国正
WU Lili;MENG Hui;WU Ali;PENG Weifeng;SU Qinghua;LI Guozheng(Department of Neurology,Zhoukou Hospital of Traditional Chinese Medicine,Zhoukou 466000,Henan,China;Zhoukou Chucmhui District Hosbital of Trcalitional Chinese Medicine,Zhoukou 466002,Henan,China;Department of Obstetrics and Gynecology,Zhoukou Hospital of Traditional Chinese Medicine,Zhoukou 466000,Henan,China;College of Life Science and Agriculture,Zhoukou Normal University,Zhoukou 466001,Henan,China;Linzhou hospital of Tracditional Chinese Medicine,Linzhou,456550,Henan,China)
出处
《实用中医内科杂志》
2019年第11期21-23,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
2018年河南省中医药科学研究专项课题(2018ZY3061)
