摘要
补体应答基因32(RGC32)是一种重要的补体应答基因,同时在细胞周期调控、促进组织细胞间质转化、免疫的调节、肿瘤的转移等过程中也起到关键作用。RGC32可在多种正常组织及肿瘤中广泛表达,其异常表达具有肿瘤相关性和组织差异性,如在结直肠癌、胰腺癌、乳腺癌、胃癌、卵巢癌等多种肿瘤中具有正向调控作用,在神经胶质瘤、多发性骨髓瘤中发挥反向的调节作用,在非小细胞肺癌中既可起到抑制作用又可起到促进作用。目前关于RGC32在肿瘤中的作用尚未形成统一的观点,文章就RGC32在肿瘤中的研究进行综述。
Complement response gene 32(RGC32)is an important complement response gene,which plays a key role in the regulation of cell cycle,epithelial-mesenchymal transformation,immune and tumor metastasis.RGC32 is widely expressed in a variety of normal tissues and tumors.Its abnormal expression has tumor-relevant and tissue-differentiated characteristics.For example,RGC32 has a positive regulatory role in colorectal cancer,pancreatic cancer,breast cancer,gastric cancer,ovarian cancer and other tumors,but it has a reverse regulatory role in glioma,multiple myeloma.It can also play an inhibitory and stimulative role in nonsmall cell lung cancer.At present,there is no consensus on the role of RGC32 in tumors.This article reviews the research progress of RGC32 in tumors.
作者
禹乐(综述)
余英豪(审校)
YU Le;YU Ying-hao(Department of Pathology,the 909th Hospital of Joint Logistics Support Force,Zhangzhou 363000,Fujian,China;Department of Pathology,the 900th Hospital of Joint Logistics Support Force,Fuzhou 350025,Fujian,China)
出处
《东南国防医药》
2020年第1期71-75,共5页
Military Medical Journal of Southeast China
关键词
补体应答基因32
肿瘤
细胞增殖分化
上皮间质转化转
complementresponsegene 32
tumor
cellproliferationanddifferentiation
epithelial-mesenchymaltransformation
