摘要
目的 探讨头孢哌酮/舒巴坦在老年脑梗死(CI)患者肺部感染(PI)治疗中的应用效果。方法 因CI并发PI(CI-PI)在我科治疗的162例患者,按照随机数字表法分为试验组和对照组各81例。在常规CI治疗基础上,对照组给予头孢他啶治疗,试验组给予头孢哌酮/舒巴坦治疗。观察治疗前后两组血二氧化碳分压(PaCO 2)、氧分压(PaO 2)、pH值等血气分析指标,第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)等肺功能指标,血清IgA、IgG、IgM等免疫因子,白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)等炎性因子。结果 治疗后,两组PaO 2、pH值、FEV 1、FVC、IgA、IgG、IgM等较治疗前升高,PaCO 2、IL-6、IL-8、TNF-α较治疗前降低,试验组PaO 2、pH值、FEV 1、FVC、IgA、IgG、IgM及总有效率高于对照组,PaCO 2、IL-6、IL-8、TNF-α低于对照组(P<0.05)。结论 头孢哌酮/舒巴坦治疗老年CI-PI可提高患者免疫能力,杀灭病原体,清除患者炎性因子,改善肺功能及血气分析指标,疗效显著。
Objective To investigate the application effect of cefoperazone/sulbactam in the treatment of pulmonary infection(PI)in elderly patients with cerebral infarction(CI).Methods One hundred and sixty-two CI-PI patients treated in our department were divided into experimental or control group,81 in each group according to random number table method.On the basis of routine CI treatment,the control group was given ceftazidime treatment while the experimental group was given cefoperazone/sulbactam treatment.The blood gas indexes such as PaCO2,PaO2 and pH,the pulmonary function indexes such as forced expiratory volume(FEV1)and forced vital capacity(FVC),the immune factors such as serum IgA,IgG,IgM,and the inflammatory factors such as interleukin-6(IL-6),interleukin-8(IL-6),tumor necrosis factor-α(TNF-α)were observed before and after treatment.Results After treatment,PaO2,pH,FEV1,IgA,IgG and IgM were increased while PaCO2,IL-6,IL-8,TNF-αwere decreased in the two groups when compared with those before treatment.PaO2,pH,FEV1,IgA,IgG and IgM were higher while PaCO2,IL-6,IL-8,TNF-αwere lower in the experimental group than those in the control group(P<0.05).The total effective rate of the experimental group was higher than that of the control group(P<0.05).Conclusion Cefoperazone/sulbactam treatment of CI-PI in the elderly can improve the immunity of patients,kill the pathogens,eliminate the inflammatory factors of patients,and improve the lung function and the blood gas analysis indicators.The therapy has obvious curative effect.
作者
李艳芳
陈骥
贾志华
马春兰
LI Yan-fang;CHEN Ji;JIA Zhi-hua;MA Chun-lan(Department of Infectious Diseases,The First Affiliated Hospital,Chengdu Medical College,Chengdu,610500,China;Department of Respiratory Medicine,The First Affiliated Hospital,Chengdu Medical College,Chengdu,610500,China)
出处
《实用医院临床杂志》
2020年第1期131-134,共4页
Practical Journal of Clinical Medicine
关键词
头孢哌酮/舒巴坦
老年
脑梗死
肺部感染
疗效
Cefoperazone/sulbactam
Old age
Cerebral infarction
Pulmonary infection
Curative effect
