摘要
信号转导和转录激活因子3(STAT3)是信号转导和转录激活因子的一种,其作用体现在细胞信号的交流和基因的转录等方面,Janus蛋白酪氨酸激酶2(JAK2)/STAT3/缺氧诱导因子-1α(HIF-1α)信号通路对脑卒中的影响极为重要。然而,JAK2/STAT3/HIF-1α信号通路在大脑中所起到的具体作用,尤其是在脑卒中之后是保护或是损害,至今仍无定论。该文阐述JAK2/STAT3/HIF-1α信号通路的激活或抑制在脑卒中(特别是脑缺血再灌注)中所发挥的作用,提出脑卒中急性期抑制JAK2/STAT3/HIF-1α信号通路的表达、康复期激动JAK2/STAT3/HIF-1α信号通路的表达、抑制与激动的结合运用可能是今后对JAK2/STAT3/HIF-1α信号通路的研究方向。
Signal transducer and activator of transcription 3(STAT3) is one of the signal transducers and activators of transcription, which plays an important role in signal communication and gene transcription in cells. The Janus kinase 2(JAK2)/STAT3/hypoxia inducible factor(HIF)-1α signaling pathway is extremely crucial to brain following stroke. However, the specific role of the activation of JAK2/STAT3/HIF-1α signaling pathway to the brain is still unknown, especially regarding whether it protects or damages the brain after stroke. In this article, the effect of the activation or inhibition of JAK2/STAT3 signaling pathway upon the brain after stroke was illustrated. Suppressing the expression of JAK2/STAT3/HIF-1α signaling pathway in acute stroke, exciting and suppressing combined with exciting the expression of JAK2/STAT3/HIF-1α signaling pathway during rehabilitation may become the research direction of JAK2/STAT3/HIF-1α signaling pathway.
作者
林建国
刘冰冰
梁飞
范杞森
潘晓燕
肖晓山
Lin Jianguo;Liu Bingbing;Liang Fei;Fan Qisen;Pan Xiaoyan;Xiao Xiaoshan(Guangdong Medical University,Zhanjiang 524023,China)
出处
《新医学》
2020年第1期6-11,共6页
Journal of New Medicine
基金
广东省自然科学基金（2018A030313646）
