摘要
目的探讨卵巢癌患者血小板与淋巴细胞比值(PLR)、人附睾蛋白4(HE4)及糖类抗原125(CA125)的表达水平及其意义。方法选取2012年1月至2018年6月该院就诊的70例卵巢癌患者(卵巢癌组)和体检的70例健康妇女(对照组),检测两组PLR、HE4及CA125水平,并按照国际妇产科协会(FIGO)分期、分化程度、是否具有淋巴结转移进行分组分析。结果卵巢癌组PLR[(175.6±44.8)vs.(116.2±33.4)]、HE4[(336.2±98.4)pmol/L vs.(54.1±9.5)pmol/L]及CA125[(433.9±167.8)U/mL vs.(19.6±5.2)U/mL]明显高于对照组,差异有统计学意义(P<0.05);Ⅲ期和Ⅳ期卵巢癌患者PLR[(210.6±41.7)vs.(148.2±42.4)]、HE4[(516.4±90.0)pmol/L vs.(270.3±88.1)pmol/L]及CA125[(628.9±148.1)U/mL vs.(367.1±125.4)U/mL]明显高于Ⅰ期和Ⅱ期,差异有统计学意义(P<0.05);低分化卵巢癌患者PLR[(220.5±35.1)vs.(151.3±42.7)]、HE4[(429.8±98.4)pmol/L vs.(285.1±98.4)pmol/L]及CA125[(541.8±144.2)U/mL vs.(388.2±162.8)U/mL]明显高于高分化及中分化患者,差异有统计学意义(P<0.05);有淋巴结转移的卵巢癌组患者PLR[(206.3±42.6)vs.(150.1±43.2)]、HE4[(381.8±89.6)pmol/L vs.(296.3±92.4)pmol/L]及CA125[(496.4±155.0)U/mL vs.(389.1±143.9)U/mL]明显高于无淋巴结转移患者,差异有统计学意义(P<0.05)。结论卵巢癌患者PLR、HE4及CA125表达水平明显升高,且随着FIGO分期、分化程度及淋巴结转移的恶化进一步升高。
Objective To investigate the levels and significance of platelet-lymphocyte ratio(PLR),human epididymis protein 4(HE4)and carbohydrate antigen 125(CA125)in patients with ovarian cancer.Methods A total of 70 patients with ovarian cancer(the ovarian cancer group)and 70 healthy women(the control group)were enrolled from January 2012 to June 2018.The levels of PLR,serum HE4 and CA125 in the two groups were tested and grouped according to international federation of gynecology and obstetrics(FIGO)stage,degree of differentiation,and lymph node metastasis.Results In the ovarian cancer group,PLR[(175.6±44.8)vs.(116.2±33.4)],HE4[(336.2±98.4)pmol/L vs.(54.1±9.5)pmol/L]and CA125[(433.9±167.8)U/mL vs.(19.6±5.2)U/mL]were significantly higher than those in the control group,the difference was statistically significant(P<0.05).In stageⅢandⅣovarian cancer patients,PLR[(210.6±41.7)vs.(148.2±42.4)],HE4[(516.4±90.0)pmol/L vs.(270.3±88.1)pmol/L]and CA125[(628.9±148.1)U/mL vs.(367.1±125.4)U/mL]were significantly higher than those in stageⅠandⅡ,the difference was statistically significant(P<0.05).In poorly differentiated ovarian cancer patients,PLR[(220.5±35.1)vs.(151.3±42.7)],HE4[(429.8±98.4)pmol/L vs.(285.1±98.4)pmol/L]and CA125[(541.8±144.2)U/mL vs.(388.2±162.8)U/mL]were significantly higher than those in well differentiated and moderately differentiated patients,the difference was statistically significant(P<0.05).In patients with lymph node metastasis,PLR[(206.3±42.6)vs.(150.1±43.2)],HE4[(381.8±89.6)pmol/L vs.(296.3±92.4)pmol/L]and CA125[(496.4±155.0)U/mL vs.(389.1±143.9)U/mL]were significantly higher than those in the patients without lymph node metastasis,the difference was statistically significant(P<0.05).Conclusion The levels of PLR,HE4 and CA125 in patients with ovarian cancer are significantly elevated,which increase with the deterioration of FIGO stage,differentiation and lymph node metastasis.
作者
孟立群
朱海萍
章宇
MENG Liqun;ZHU Haiping;ZHANG Yu(Department of Gynecology,Zhuji Central Hospital,Zhuji,Zhejiang 311800,China)
出处
《重庆医学》
CAS
2020年第2期219-222,共4页
Chongqing medicine
基金
浙江省自然科学基金项目（LY17C040001）
