摘要
目前被美国食品药品监督管理局批准用于治疗原发性胆汁性胆管炎(PBC)的药物包括熊去氧胆酸和奥贝胆酸。对熊去氧胆酸应答不佳、不能耐受奥贝胆酸瘙痒副作用的患者亟需新的治疗药物。近年来大量基础实验和临床研究认为贝特类药物对PBC疗效显著。就贝特类药物治疗原发性胆汁性胆管炎的机制进展及临床应用作一综述。
At present, ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are approved by FDA for the treatment of primary biliary cholangitis (PBC). New drugs are urgently needed for the patients who have inadequate response to UDCA or cannot tolerate pruritus, a common side effect of OCA. In recent years, a large number of basic experiments and clinical studies have shown that fibrates have a good clinical effect in the treatment of PBC. This article reviews the advances in the mechanism and clinical application of fibrates in the treatment of PBC.
作者
卫晶
武希润
WEI Jing;WU Xirun(Department of Gastroenterology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第2期442-445,共4页
Journal of Clinical Hepatology
