摘要
目的:探讨高剂量促红素治疗维持性血液透析伴高血压的药学效果。方法:以2018年1-12月于笔者所在医院接受维持性血液透析伴高血压患者作为本次研究对象,共64例。按照入院顺序分为对照组和观察组,各32例。对照组实施低剂量促红素治疗,观察组实施高剂量促红素治疗。对比两组血压、血常规水平。根据治疗前后血细胞比容(HCT)变化情况,将患者分为A组(HCT增幅<4%)和B组(HCT增幅≥4%),比较两组血压水平。结果:观察组总有效率为93.75%,对照组总有效率为90.63%,差异无统计学意义(P>0.05);治疗前两组血压、血常规水平对比,差异均无统计学意义(P>0.05);治疗后观察组各项指标水平均高于对照组,差异均有统计学意义(P<0.05);治疗前A组和B组血压水平比较,差异均无统计学意义(P>0.05);治疗后B组血压水平均高于A组,差异均有统计学意义(P<0.05)。结论:对维持性血液透析伴高血压患者实施促红素治疗,高剂量和低剂量的临床效果相似。但使用高剂量促红素治疗容易导致患者血压升高,且以HCT增幅≥4%患者最为明显。
Objective:To study the pharmacologic effect of high-dose Erythropoietin in the treatment of maintenance hemodialysis with hypertension.Method:A total of 64 patients with maintenance hemodialysis with hypertension in our hospital from January to December 2018 were selected as the subjects of this study.Patients were divided into the control group and the observation group according to the order of admission,32 cases in each group.The control group was treated with low-dose of Erythropoietin,while the observation group was treated with high-dose of Erythropoietin.The levels of blood pressure and blood routine of the two groups were compared.According to the changes of hematocrit(HCT)before and after treatment,patients were divided into the group A(HCT growth<4%)and the group B(HCT growth≥4%),and the levels of blood pressure of the two groups were compared.Result:The total effective rate of the observation group was 93.75%,and the total effective rate of the control group was 90.63%,and the difference was not statistically significant(P>0.05).Before treatment,the levels of blood pressure and blood routine were compared between the two groups,and the differences were not statistically significant(P>0.05).After treatment,all indexes in the observation group were higher than those of the control group,and the differences were statistically significant difference(P<0.05).Before treatment,the levels of blood pressure of the group A and the group B were compared,and the differences were not statistically significant(P>0.05).After treatment,the levels of blood pressure in the group B were higher than those of the group A,and the differences were statistically significant difference(P<0.05).Conclusion:Patients with maintenance hemodialysis with hypertension are treated with Erythropoietin,the clinical effect of high-dose and low-dose is similar.However,high-dose Erythropoietin is likely to lead to increased blood pressure in patients,and patients with HCT growth≥4%is most obvious.
作者
吕庆芳
郑君安
武磊
LYU Qingfang;ZHENGJun’an;WU Lei(Xiaochang County First People’s Hospital,Xiaochang 432900,China)
出处
《中外医学研究》
2020年第1期17-19,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
促红素
高剂量
维持性血液透析
高血压
Erythropoietin
High-dose
Maintenance hemodialysis
Hypertension
