摘要
目的探讨糖尿病冠状动脉粥样硬化性心脏病(简称糖尿病冠心病)患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)和血脂(TG、HDL-C、LDL-C、Lp(a)、ApoA1、ApoB和ApoB/ApoA1比值)水平的临床价值。方法采用酶联免疫分析、生化法和免疫比浊分析测定157例糖尿病冠心病患者血清Lp-PLA2和血脂水平,并与60名健康对照组进行比较性分析。结果糖尿病冠心病患者血清Lp-PLA2、TG、LDL-C、Lp(a)、ApoB和ApoB/ApoA1比值水平明显增高,而血清HLD-C、ApoA1水平稍降低。结论糖尿病冠心病的特点是血糖和血脂代谢紊乱,胰岛素抵抗和高尿酸血症,血清Lp-PLA2、LDL-C、ApoA1、ApoB和ApoB/ApoA1比值测定具有早期诊断的临床价值,血清Lp-PLA2、LDL-C、ApoA1和ApoB水平是预测冠心病心血管事件的有价值指标。
Objective to investigate clinical value of serum lipoprotein associated phospholipase A2(Lp-PLA2)and serum lipids(TG,HDL-C,LDL-C,LP(a),ApoA1,apoB and apoB/ApoA1 ratio)of patients with diabetic coronary atherosclerotic heart disease.Methods determine levels of Lp-PLA2 and lipid in 157 cases diabetic coronary heart disease patients with enzyme-linked immunosorbent assay,biochemical method and immunoturbidimetry.Compared data with 60 healthy controls.Results serum levels of Lp-PLA2,TG,LDL-C,LP(a),apoB and apoB/ApoA1 ration were significantly increased,while serum levels of hld-c and ApoA1 were slightly decreased.Conclusion diabetic coronary heart disease has characters of blood glucose and lipid metabolism disorder,insulin resistance and hyperuricemia.Determination of serum Lp-PLA2,LDL-C,ApoA1,apoB and apoB/ApoA1 ratio has clinical value for early diagnosis.And levels of serum Lp-PLA2,LDL-C,ApoA1 and apoB are valuable indexes for predicting cardiovascular events of coronary heart disease.
作者
张天琦
陈旭东
ZHANG Tian-qi;CHEN Xu-dong(Jilin Central Hospital,Jilin,Jilin 132011)
出处
《智慧健康》
2019年第33期5-6,共2页
Smart Healthcare
关键词
血脂
稳定性
冠状动脉粥样硬化性心脏病
糖尿病
炎症
Blood lipid
Stability
Coronary atherosclerotic heart disease
Diabetes
Inflammation
