摘要
目的探讨术前同步放化疗联合手术治疗食管癌的临床效果。方法选择2016年1月~2018年12月新疆医科大学附属肿瘤医院收治的51例食管癌患者,根据随机数字表法将其分为观察组(n=27)和对照组(n=24)。观察组在术前行多西他赛+顺铂化疗,并同步进行三维适形放疗,于化疗2周后进行手术。对照组直接进行手术治疗。比较两组患者手术完全切除情况,围术期并发症发生情况,1、2年和3年生存率。记录观察组近期疗效和毒副作用发生情况。结果剔除随访失访病例后,观察组剩余26例,对照组剩余22例。观察组患者经术前同步放化疗治疗后客观缓解率(ORR)为92.31%,疾病控制率(DCR)为100.00%。观察组患者中Ⅲ级及以上急性毒副作用包括中性粒细胞减少2例、血小板减少1例、恶心/呕吐4例、脱发5例、放射性皮炎1例。观察组完全性切除率及术后1、2年和3年生存率显著高于对照组,差异有统计学意义(P<0.05)。两组患者围术期并发症发生率比较,差异无统计学意义(P>0.05)。结论术前同步放化疗联合手术治疗能够提高试管鳞癌患者生存率和完全性切除率。
Objective To investigate the clinical effect of preoperative concurrent chemoradiotherapy combined with surgery in the treatment of esophageal cancer.Methods From January 2016 to December 2018,51 patients with esophageal cancer admitted to the Tumor Hospital Affiliated to Xinjiang Medical University were selected and divided into the observation group(n=27)and the control group(n=24)according to the random number table method.The observation group received Docetaxel+Cisplatin chemotherapy before surgery,and received three-dimensional conformal radiotherapy simultaneously.Surgery was performed 2 weeks after chemotherapy.The control group received surgical treatment directly.The complete resection,perioperative complications,1-year,2-year and 3-year survival rates of patients were compared between the two groups.The occurrence of short-term curative effect and toxic side effect in the observation group was recorded.Results After eliminating the lost follow-up cases,26 cases remained in the observation group and 22 cases in the control group.The objective remission rate(ORR)and disease control rate(DCR)were 92.31%and 100.00%respectively in the observation group after preoperative concurrent chemoradiotherapy.In the observation group,acute toxic side effects of gradeⅢor above included neutropenia in 2 cases,thrombocytopenia in 1 case,nausea/vomiting in 4 cases,alopecia in 5 cases and radiation dermatitis in 1 case.The complete resection rate and 1-year,2-year and 3-year survival rate in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of perioperative complications between the two groups(P>0.05).Conclusion Preoperative concurrent chemoradiotherapy combined with surgical treatment can improve the survival rate and complete resection rate of patients with in vitro squamous cell carcinoma.
作者
巴尔夏古丽·扎比胡拉
穆克代斯·伊力亚斯
Balshaguri·Zabihuula;Mukhdes·Ilias(Department of Thoracic and Abdominal Radiotherapy,Tumor Hospital Affiliated to Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830011,China)
出处
《中国医药导报》
CAS
2020年第4期106-109,共4页
China Medical Herald
基金
新疆维吾尔自治区自然科学基金项目（2016D01C356）
关键词
食管癌
术前
同步放化疗
外科治疗
生存率
Esophageal cancer
Preoperative
Concurrent chemoradiotherapy
Surgical treatment
Survival rate
