摘要
目的综述近年来创伤性毛囊新生(wound-induced hair follicle neogenesis,WIHN)细胞来源及相关信号通路的研究进展。方法广泛查阅近年与WIHN相关的文献,从细胞来源、分子机制等方面进行总结讨论。结果WIHN是一种罕见的成年哺乳动物毛囊再生现象,新生毛囊细胞来源丰富,既有创面周围来源的毛囊干细胞,也有上皮来源的干细胞。WIHN分子机制复杂,是一种多种信号通路调控的再生过程,与免疫系统密切相关,免疫细胞及其产生的各种免疫因子为这一过程提供了适宜的条件。结论WIHN的细胞来源及分子机制等方面仍有许多未解决的问题,加强机制研究将加深对成年哺乳动物毛囊再生的了解,为皮肤功能性愈合提供新思路。
Objective To explore the research progress of the cell sources and related signaling pathways of the wound-induced hair follicle neogenesis(WIHN)in recent years.Methods The literature related to WIHN in recent years was reviewed,and the cell sources and molecular mechanism were summarized and discussed.Results Current research shows that WIHN is a rare regeneration phenomenon in the skin of adult mammals,with multiple cell origins,both hair follicle stem cells and epithelial stem cells around the wound.Its molecular mechanism is complicated,which is regulated by many signaling pathways.Besides,the process is closely related to the immune response,the immunocytes and their related cytokines provide suitable conditions for this process.Conclusion There are still many unsolved problems on the cellular origins and molecular mechanisms of the WIHN.Further study on the mechanisms will enhance the understanding of adult mammals’hair follicle regeneration and may provide new strategy for functional healing of the human skin.
作者
刘鹏程
谭秋雯
江燕林
吕青
LIU Pengcheng;TAN Qiuwen;JIANG Yanlin;LU Qing(Department of Breast Surgery,Clinical Research Center for Breast Disease,West China Hospital,Sichuan University,Chengdu Sichuan,610041,P.R.China;Laboratory of Stem Cell and Tissue Engineering,West China Hospital,Sichuan University,Chengdu Sichuan,610041,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2020年第3期393-398,共6页
Chinese Journal of Reparative and Reconstructive Surgery
基金
中国博士后科学基金资助项目(2018M633372)
四川省科技计划项目(2019YJ0052)
四川大学华西医院专职博士后项目(2018HXBH026)。
关键词
创伤性毛囊新生
胚胎样再生
皮肤愈合
功能性再生
Wound-induced hair follicle neogenesis
embryogenic regeneration
skin healing
functional regeneration
