摘要
本文通过N-取代芳磺酰胺和N,N′-环氮甲基亚胺发生[4+3]环加成反应,得到了一种高效合成三环苯并三氮杂[艹卓]衍生物的方法。对该反应的条件如溶剂和碱进行了筛选,在最优条件下,考察了底物普适性,并合成了9个苯并三氮杂[艹卓]衍生物,收率为36~99%。所有目标化合物通过^1H NMR、^13C NMR和HRMS进行了结构确证。
A[4+3]cycloaddition reaction of N,N′-cyclic azomethine imines with N-substituted aromatic sulfonamide had been developed.The text provided a rapid method for the synthesis of tricyclic benzotriazepines.The reaction conditions which mainly included solvent and base had been screened.Under the optimum reaction condition,nine tricyclic benzotriazepines had been obtained in 36~99%yield range.The structures of all target compounds were characterized by 1H NMR,13 C NMR and HRMS.
作者
于姝燕
王敏
陈建平
王建华
张可青
郭晓宇
YU Shu-yan;WANG Min;CHEN Jian-ping;WANG Jian-hua;ZHANG Ke-qing;GUO Xiao-yu(College of Pharmacy,Inner Mongolia Medical University,Hohhot 010010,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2020年第3期473-477,共5页
Chemical Research and Application
基金
内蒙古自治区自然科学基金项目(2018MS02009)资助
内蒙古自治区大学生创新创业训练计划项目(201910132009)资助
内蒙古医科大学科技百万工程项目(YKD2017KJBW013)资助
内蒙古医科大学本科质量工程“教坛新秀”项目(NYJTXX201802)资助。
