原发性消化道肿瘤对患者免疫细胞影响的临床观察被引量：4

Clinical Observation on the Effect of Primary Digestive Tumor on the Immunocytes Levels of Patients

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摘要目的探究不同部位原发性消化道肿瘤对患者免疫细胞的影响。方法将2012年1月至2018年8月在华中科技大学医院外科住院部或门诊首次诊断为消化道肿瘤并符合纳入标准患者279例纳入研究,根据肿瘤发生部位分为,原发性肝癌组63例,原发性胃癌组71例,原发性十二指肠癌组33例,原发性空肠癌组5例,原发性回肠癌组3例,原发性结肠癌组22例,原发性直肠癌组82例。收集各患者静脉血血细胞化验单,记录中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞绝对值,采用SPSS统计软件比较各组间数值差异,并根据上下消化道分界线Treitz韧带(屈氏韧带)分为上消化道组167例、下消化道组112例,同样比较两组白细胞水平。结果肝癌、结肠癌、直肠癌组中性粒细胞水平明显较高(P<0.01);结肠癌、直肠癌组淋巴细胞水平明显较高,P<0.01;回肠癌、结肠癌、直肠癌组嗜酸性粒细胞水平明显较高(P<0.01);与上消化道组相比,下消化道组中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞绝对值较高(P<0.01)。结论下消化道恶性肿瘤患者血常规中中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞水平要显著高于上消化道恶性肿瘤患者,中性粒细胞水平在肝癌、结肠、直肠癌患者中增加明显,淋巴细胞、嗜酸性粒细胞在结肠、直肠癌患者中增加明显,在回肠癌时嗜酸性粒细胞也有增加。 Objective To investigate the effect of primary digestive tumor on the immunocytes levels of patients.Methods From January 2012 to August 2018 the 279 cases diagnosed as primary digestive tumor complying with the inclusion criteria in Oncology Department or Outpatient Department in Huazhong Technology University Hospital were selected as the research subjects.According the Tumor location they were divided into primary liver tumor group(63 cases),primary gastric tumor group(71cases),primary duodenal tumor group(33 cases),primary empty bowel group(5 cases),primary ilium tumor group(3cases),primary colon tumor group(22 cases)and primary rectum tumor group(82 cases).The blood checking reports of each patient's vessel blood were collected,the absolute values of Neutrophile,Granulocyte,Lymphocyte,Monocyte,Eosinophile,Granulocyte,Basophile Granulocyte were recorded and analyzed by SPSS statistical software.According to the Treitz ligament the groups above were divided into upper digestive tract group(167cases)and lower digestive tract group(168cases),the corresponding immunocytes were analyzed in the same way.Results The Neutrophile Granulocyte levels of liver tumor group,colon tumor group and rectum tumor group were higher(P<0.01);The lymphocyte levels of colon tumor group and rectum tumor group were higher P<0.01;The Eosinophile Granulocyte levels of ilium tumor,colon tumor and rectum tumor group were higher P<0.01;Compared with the upper digestive tract group the levels of Neutrophile Granulocyte,Lymphocyte,Monocyte,Eosinophile Granulocyte were obviously higher(P<0.01).Conclusions Compared with the upper digestive tract group the levels of Neutrophile Granulocyt,Lymphocyt,Monocyt,Eosinophile Granulocyte are obviously higher.The Neutrophile Granulocyte levels of liver tumor group,colon tumor group and rectum tumor group are higher.The lymphocyte levels of colon tumor group and rectum tumor group are higher.The Eosinophile Granulocyte levels of ilium tumor,colon tumor and rectum tumor group are higher.

作者杨帆张弦张勇王瑶瑶 YANG Fan;ZHANG Xian;ZHANG Yong;WANG Yao-yao(Dept.of Surgery,Huazhong Technology University Hospital,Wuhan Hubei 430070;Dept.of Gastrointestinal Surgery,Huarun Wugang General Hospital;Dept.of General Surgery,Xiehe Hospital Huazhong,Tongji Medical College,Technology University,Wuhan Hubei 430080,China)

机构地区华中科技大学医院外科华润武钢总医院胃肠外科华中科技大学同济医学院附属协和医院普外科

出处《昆明医科大学学报》 CAS 2020年第1期57-62,共6页 Journal of Kunming Medical University

基金国家自然科学基金资助项目(8157041114) 武汉市晨光计划基金资助项目(2016070204010122)。

关键词原发性消化道肿瘤免疫细胞绝对值相关性 Primary digestive tract tumor Immunocyte Absolute value Relativity

分类号 R735 [医药卫生—肿瘤]

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参考文献4

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