摘要
目的探讨慢性心力衰竭患者血清氨基末端脑钠肽前体(NT-proBNP)和心肌肌钙蛋白I(cTnI)联合检测的临床意义。方法选取2018年3~12月我院收治的49例慢性心力衰竭患者作为观察组,选择同期我院的49例健康体检者作为对照组,进行回顾性分析。采用纽约心脏病协会(NYHA)心功能分级方法,将观察组进一步分为:NYHAⅡ级观察组(17例)、NYHAⅢ级观察组(16例)、NYHAⅣ级观察组(16例)。观察组患者与对照组患者均接受胶乳增强免疫比浊法、对抗体夹心免疫法检测。比较两组患者的cTnI、NT-proBNP浓度;比较NYHAⅡ、Ⅲ、Ⅳ级观察组患者的cTnI、NT-proBNP浓度;比较cTnI、NT-proBNP浓度联合检测与单一检测在观察组患者中的真阳性率差异。结果观察组患者的cTnI与NT-proBNP均高于对照组,差异有统计学意义(P<0.05);NYHAⅡ级观察组患者的cTnI、NT-proBNP浓度均低于NYHAⅢ、Ⅳ级观察组,差异有统计学意义(P<0.05);NYHAⅣ级观察组患者的cTnI、NT-proBNP浓度高于NYHAⅢ级观察组,差异有统计学意义(P<0.05);观察组患者cTnI+NT-proBNP联合检测的真阳性率,高于cTnI、NT-proBNP单一检测,差异有统计学意义(P<0.05)。观察组患者cTnI单一检测的真阳性率低于NT-proBNP单一检测,差异有统计学意义(P<0.05)。结论血清NT-proBNP和cTnI联合检测的方法,可有效提高慢性心力衰竭患者的检出率,值得推广使用。
Objective To investigate the clinical significance of combined detection of serum aminoterminal brain natriuretic peptide(NT-proBNP)and cardiac troponin I(cTnI)in patients with chronic heart failure.Methods Forty-nine patients with chronic heart failure admitted to our hospital from March to December 2018 were selected as the observation group,and 49 healthy patients in our hospital during the same period were selected as the control group for retrospective analysis.The New York Heart Association(NYHA)cardiac function classification method was used to further divide the observation group into:NYHAⅡobservation group(17 cases),NYHAⅢobservation group(16 cases),NYHAⅣobservation group(16 cases).Both the observation group and the control group received latex-enhanced immunoturbidimetry and antibody sandwich immunoassay.The concentrations of cTnI and NT-proBNP were compared between the two groups.The concentrations of cTnI and NT-proBNP were compared in the NYHAⅡ,Ⅲ,andⅣobservation groups.The true positive rate of cTnI,NT-proBNP concentration combined detection and single detection in the observation group was compared.Results The cTnI and NT-proBNP in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The cTnI and NT-proBNP concentrations in the NYHAⅡobservation group were lower than those in the NYHAⅢandⅣobservation group,the differences were statistically significant(P<0.05).The concentration of cTnI and NT-proBNP in NYHAⅣobservation group were higher than those in NYHAⅢobservation group,the differences were statistically significant(P<0.05).The true positive rate of cTnI+NT-proBNP combined detection was higher than that of cTnI and NT-proBNP single detection,and the differences were statistically significant(P<0.05).In the observation group,the true positive rate of cTnI single detection was lower than that of NT-proBNP single detection, and the difference was statistically significant (P<0.05). Conclusion The combined detection of serum NT-proBNP and cTnI can effectively improve the detection rate of patients with chronic heart failure, which is worthy of popularization.
作者
刘颁
LIU Ban(The Third Department of Cardiology,Liaoning Provincial Health Industry Group Iron and Coal General Hospital,Tieling112700,China)
出处
《中国当代医药》
2020年第7期51-54,共4页
China Modern Medicine
关键词
慢性心力衰竭
联合检测
心肌肌钙蛋白I
血清氨基末端脑钠肽前体
Chronic heart failure
Combined detection
Cardiac troponin I
Serum amino terminal brain natriuretic peptide precursor
