摘要
目的观察复方皂矾丸辅助治疗耐多药肺结核病的临床效果。方法选取2016年6月~2018年12月我院收治的40例耐多药肺结核病(MDR-TB)患者作为研究对象,根据随机数字表法分为实验组与对照组,每组各20例,两组均根据既往用药史和药敏试验结果采用3~5种敏感抗结核药物行常规基础化疗,实验组则在原基础上加用复方皂矾丸口服。观察患者治疗后痰菌转阴、病灶吸收、空洞闭合率、T细胞亚群变化情况。结果两组患者治疗1、2、3、4、5、6个月后痰菌阴转率比较,差异无统计学意义(P>0.05),两组患者治疗6个月后总有效率比较,差异无统计学意义(P>0.05),但实验组治疗3个月后血清CD4^+、CD4^+/CD8^+及治疗6个月后空洞闭合率高于对照组,CD8+低于对照组,差异有统计学意义(P<0.05)。结论复方皂矾丸辅助治疗耐多药肺结核可增加患者肺部空洞吸收率,显著提高机体细胞免疫功能,改善患者预后。
Objective To observe the clinical effect of Compound Saponin Pills in the treatment of multidrug-resistant tuberculosis.Methods Forty patients with multidrug-resistant tuberculosis admitted to our hospital from June 2016 to December 2018 were selected as subjects.According to the random number table method,they were divided into experimental group and control group,20 cases in each group.The two groups were used 3 to 5 sensitive anti-tuberculosis drugs according to the previous medication history and drug susceptibility test results.Conventional basic chemotherapy,the experimental group was added with Compound Saponin Pills orally on the original basis.The sputum negative conversion,chest X-ray lesion absorption,cavity closure rate and T cell subsets were observed after treatment in the two groups.Results There was no significant difference in the rate of sputum negative conversion between the two groups after 1,2,3,4,5,6 months of treatment(P>0.05),there was no significant difference in the total effective rate between the two groups after 6 months of treatment(P>0.05),but serum CD4^+,CD4^+/CD8^+in the experimental group after treatment for 3 months and the cavity closure rate after treatment for 6 months were higher than those of the control group,and the CD8+was lower than that of the control group.The differences were statistically significant(P<0.05).Conclusion Compound Saponin Pills for the treatment of multidrug-resistant tuberculosis can increase the lung cavity absorption rate,significantly improve the cellular immune function and improve the prognosis of patients.
作者
程吕欢
邓建仟
李娅娜
舒维
CHENG Lyu-huan;DENG Jian-qian;LI Ya-na;SHU-Wei(Department of Thoracic Surgery,Jiangxi Chest Hospital,Jiangxi Province,Nanchang330006,China;Department of Tuberculosis,Jiangxi Chest Hospital,Jiangxi Province,Nanchang330006,China;Department of Diagnosis,Jiangxi Chest Hospital,Jiangxi Province,Nanchang330006,China)
出处
《中国当代医药》
2020年第6期36-39,共4页
China Modern Medicine
基金
江西省卫生计生委中医药科研课题(2016A108)。
关键词
复方皂矾丸
耐多药肺结核病
细胞免疫功能
肺结核
Compound Saponin Pills
Multidrug-resistant tuberculosis
Cellular immune function
Tuberculosis
