摘要
目的探讨术前纤维蛋白原与白蛋白比值(fibrinogen and albumin ratio,FAR)对胆囊癌患者预后的判断价值。方法回顾性分析2007年2月至2019年2月于北京医院行胆囊癌根治性手术的100例患者的临床病理资料。绘制受试者工作特征(receiver operating characteristic,ROC)曲线以确定FAR的最佳界值,通过Kaplan-Meier法及单因素、多因素分析评价预后的影响因素。结果术前FAR判断术后总生存期的最佳界值为0.08。FAR与术前总胆红素(total bilirubin,TBil)水平、肿瘤分化程度、T分期、TNM分期、切缘状态、术前CA199水平显著相关(P均<0.05)。多因素分析表明,TNM分期(HR=3.562,95%CI:1.075-11.798,P=0.038)及FAR(HR=2.482,95%CI:1.263-4.875,P=0.008)是胆囊癌根治性手术后患者的独立预后因素。结论术前FAR与胆囊癌患者的预后密切相关,可能有助于评估胆囊癌患者的预后。
Objective To investigate the prognostic value of preoperative fibrinogen and albumin ratio(FAR)in patients with gallbladder carcinoma.Methods The clinicopathological data of 100 patients with gallbladder carcinoma who underwent radical surgery at Beijing Hospital from Feb 2007 to Feb 2019 were retrospectively analyzed.The receiver operating characteristic(ROC)curve was drawn to determine the optimal cut-off value of FAR,and the prognostic factors were evaluated by Kaplan-Meier method,univariate and multivariate analysis.Results The optimal cut-off value of preoperative FAR for postoperative overall survival was 0.08.FAR was significantly associated with preoperative total bilirubin(TBil)levels,tumor differentiation,T stage,TNM stage,resection margin status,and preoperative CA199 levels(all P<0.05).Multivariate analysis indicated that TNM staging(HR=3.562,95%CI:1.075-11.798,P=0.038)and FAR(HR=2.482,95%CI:1.263-4.875,P=0.008)were independent prognostic factors in patients with gallbladder carcinoma who underwent radical surgery.Conclusion Preoperative FAR is closely related to the prognosis of patients with gallbladder carcinoma and might be useful for the evaluation of prognosis of patients with gallbladder carcinoma.
作者
李锐
宋世博
李强
石晓磊
孙振
贺修文
李喆
宋京海
Li Rui;Song Shibo;Li Qiang;Shi Xiaolei;Sun Zhen;He Xiuwen;Li Zhe;Song Jinghai(Department of Hepatobiliary and Pancreatic Surgery,Beijing Hospital,National Center of Gerontology,Peking University Fifth School of Clinical Medicine,Beijing 100730,China)
出处
《中华普通外科杂志》
CSCD
北大核心
2020年第2期142-145,共4页
Chinese Journal of General Surgery
关键词
胆囊癌
纤维蛋白原
白蛋白
预后
gallbladder carcinoma
fibrinogen
albumin
prognosis
