摘要
目的探讨红花黄色素联合倍他司汀对突发性耳聋患者听阈水平、血液流变学及血脂指标的影响。方法选取2018年1月—2019年1月成都医学院第一附属医院耳鼻喉科收治的突发性耳聋患者118例,经随机数字表法分为对照组、研究组,每组各59例。对照组患者接受倍他司汀治疗,研究组患者接受红花黄色素联合倍他司汀治疗。治疗前后检测2组患者听阈水平及血液流变学指标(全血高切黏度、全血中切黏度、全血低切黏度)、血脂指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,记录治疗期间药物相关不良反应的发生情况。结果治疗1个月后,研究组总有效率为94.92%,高于对照组的81.36%(χ^2=5.187,P<0.05);研究组治疗后听阈水平降低优于对照组(t=13.539,P=0.000)。研究组治疗后全血高切黏度、全血中切黏度、全血低切黏度低于对照组(t=4.071、3.934、7.681、P<0.01);研究组治疗后外周血中TG、TC、LDL-C的水平低于对照组,HDL-C水平高于对照组(t=8.737、4.082、5.249、7.231,P<0.01)。2组患者治疗期间均未出现明显药物相关不良反应。结论红花黄色素联合倍他司汀治疗突发性耳聋,可有效改善患者听阈水平和调节患者血液流变学及血脂指标,且用药安全性较好。
Objective To explore the effect of carthamin yellow combined with betahistine on hearing threshold,hemorheology and blood lipid in patients with sudden deafness.Methods One hundred and eighteen patients with sudden deafness were selected from the Department of Otolaryngology,the First Affiliated Hospital of Chengdu Medical College from January 2018 to January 2019.Randomly divided into control group and study group,59 cases in each group.Patients in the control group were treated with betahistine,while those in the study group were treated with carthamin yellow and betahistine.Before and after treatment,the hearing threshold level,hemorheology index(whole blood high shear viscosity,whole blood medium shear viscosity,whole blood low shear viscosity),blood lipid index(TG,TC,HDL-C,LDL-C)were measured,and the occurrence of drug-related adverse reactions was recorded.Results After one month of treatment,the total effective rate of the study group was 94.92%,higher than 81.36%of the control group(χ^2=5.187,P<0.05);the hearing threshold level of the study group was lower than that of the control group(t=13.539,P=0.000).After treatment,the whole blood high shear viscosity,middle shear viscosity and low shear viscosity in the study group were lower than those in the control group(t=4.071,3.934,7.681,P<0.01);the levels of TG,TC,LDL-C in the peripheral blood in the study group were lower than those in the control group,and the levels of HDL-C were higher than those in the control group(t=8.737,4.082,5.249,7.231,P<0.01).No drug-related adverse reactions were found in the two groups.Conclusion Carthamin yellow combined with betahistine in the treatment of sudden deafness can effectively improve the hearing threshold level and regulate the hemorheology and blood lipid index of patients,and the drug safety is well.
作者
文科
侯楠
陈嘉
Wen Ke;Hou Nan;Chen Jia(Department of ENT, The First Affiliated Hospital of Chengdu Medical College, Sichuan Province,Chengdu 610500 ,China)
出处
《疑难病杂志》
CAS
2020年第4期385-388,共4页
Chinese Journal of Difficult and Complicated Cases
基金
四川省科技厅重点研发项目(19ZDYF0944)
四川省教育厅创新团队与科研项目(16ZB0274)。
关键词
突发性耳聋
红花黄色素
听阈
血液流变学
血脂
Sudden deafness
Carthamin yellow
Auditory threshold
Hemorheology
Blood lipid
