摘要
自噬是溶酶体降解受损的细胞器、蛋白质聚集体以及回收营养物质的一种分解代谢的过程。研究表明,自噬可以保护胰岛β细胞的结构,维持胰岛素的正常分泌和稳态。此外,自噬可减轻胰岛β细胞氧化应激,防止细胞凋亡以及清除泛素化蛋白聚集物等。因此,自噬在糖尿病的发生和发展过程中起着重要作用,可能成为预防和治疗糖尿病的一个新靶点。目前,噻唑烷二酮类、双胍类等临床常用降血糖药物已被证实通过可调节自噬发挥治疗作用。本文将从自噬、自噬在胰岛β细胞和糖尿病中的作用及自噬相关降血糖药物进行综述,为临床治疗糖尿病提供新的思路。
Autophagy is a catabolism process in which lysosomes degrade damaged organelles,protein aggregates and recover nutrients.Studies have shown that autophagy could protect the structure and function of isletβcell and maintaining normal secretion of insulin.In addition,autophagy plays important roles in the occurrence and development of diabetes mellitus by reducing oxidative stress,preventing apoptosis and removing ubiquitination protein aggregates.Therefore,autophagy may be a new target for the prevention and treatment of diabetes.At present,hypoglycemic drugs have been proved to play positive roles by regulating autophagy including thiazolidine dione and guanidine.Therefore,this paper will review autophagy definition,the role of autophagy in diabetes mellitus and autophagy-related hypoglycemic drugs,providing a new direction for clinical treatment of diabetes.
作者
李楚婷
赵天娇
黄琼
LI Chuting;ZHAO Tianjiao;HUANG Qiong(Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China;The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha 410008, Hunan, China;Institute of Hospital Pharmacy, Central South University, Changsha, Hunan, China;Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2020年第3期344-351,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金(81974508,81673492)。
关键词
自噬
信号通路
糖尿病
胰岛Β细胞
糖尿病药物治疗
药物靶点
autophagy
signaling pathway
diabetes mellitus
isletβcell
anti-diabetic medications
drug targets
