摘要
目的分析结直肠癌组织中紧密连接蛋白3(claudin-3)的表达情况及其与结直肠癌发生、发展、转移、预后关系。方法选择三门县人民医院2013年2月至2015年2月手术治疗的结直肠癌患者78例为研究对象,采集结直肠癌组织和癌旁组织标本,并进行claudin-3检测,分析claudin-3与结直肠癌临床病理特征的关系。结果结直肠癌组织claudin-3阳性率(83.33%)高于癌旁组织(48.72%),差异有统计学意义(χ2=20.832,P<0.01);低分化组claudin-3阳性率(100.00%)高于中分化(85.71%)及高分化组(52.63%),差异有统计学意义(χ2=19.209,P<0.01);有淋巴转移claudin-3阳性率(97.30%)高于无淋巴转移组(70.73%),差异有统计学意义(χ2=9.882,P<0.01);生存年限<3年患者的claudin-3阳性率(91.11%)高于生存年限≥3年的患者(72.73%)(χ2=4.633,P<0.05)。结论claudin-3的表达与结直肠癌的发生、发展及淋巴转移均有一定的关系,且可以预测患者的预后情况。
Objective To analyze the expression of tight junction protein 3(claudin-3)in colorectal cancer and its relationship with the development,metastasis and prognosis of colorectal cancer.Methods From February 2013 to February 2015,78 patients with colorectal cancer operated in the People's Hospital of Sanmen County were selected in this study.The tissues of colorectal cancer and adjacent tissues were collected and claudin-3 expression was detected.The relationship between claudin-3 and clinicopathological features of colorectal cancer was analyzed.Results The positive rate of claudin-3 in cancer tissues(83.33%)was higher than that in paracancerous tissues(48.72%),and the difference was statistically significant(χ2=20.832,P<0.01).The positive rate of claudin-3 in the poorly differentiated group(100.00%)was significantly higher than that in the well-differentiated group(85.71%)and the well-differentiated group(52.63%)(χ2=19.209,P<0.01).The claudin-3 positive rate with lymphatic metastasis(97.30%)was higher than that without lymphatic metastasis(70.73%),and the difference was statistically significant(χ2=9.882,P<0.01).The claudin-3 positive rate in patients with less than 3 years of survival(91.11%)was higher than that in patients with more than 3 years of survival(72.73%)(χ2=4.633,P<0.05).Conclusion The expression of claudin-3 is related to the occurrence,development and lymphatic metastasis of colorectal cancer,and can predict the prognosis of the patients.
作者
朱志华
颜崇县
孙龙
邵建力
王安华
罗叔钗
Zhu Zhihua;Yan Chongxian;Sun Long;Shao Jianli;Wang Anhua;Luo Shuchai(Department of Gastrointestinal Surgery,the People's Hospital of Sanmen County,Zhejiang 317100,China)
出处
《中国基层医药》
CAS
2020年第3期335-338,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医药卫生科技计划项目(2015DTA020)。
关键词
结直肠肿瘤
紧密连接蛋白
细胞分化
肿瘤转移
淋巴转移
存活率
预后
病理学
临床
Colorectal neoplasms
Claudins
Cell differentiation
Neoplasm metastasis
Lymphatic metastasis
Survival rate
Prognosis
Pathology
clinical
