摘要
目的:探讨腹腔镜下子宫广泛性切除术对子宫颈癌患者肿瘤坏死因子-α(TNF-α)及可溶性白细胞介素-2受体(SIL-2R)表达的影响。方法:选择63例子宫颈癌患者为观察对象,按照治疗方法分为对照组(30例)和观察组(33例),对照组行开腹广泛性子宫切除术,观察组行腹腔镜下子宫广泛性切除术。比较两组患者的一般手术情况、并发症发生情况、血清TNF-α、SIL-2R水平及预后情况。结果:观察组手术时间长于对照组,出血量少于对照组,术后排气时间、排尿功能恢复时间均短于对照组(P<0.05);两组清除淋巴结数、左侧及右侧宫旁切除长度、阴道切除长度比较,差异均无统计学意义(P>0.05);术后,两组血清TNF-α、SIL-2R水平均低于术前(P<0.05),但两组术后的血清TNF-α、SIL-2R水平比较,差异均无统计学意义(P>0.05);观察组并发症发生率低于对照组(P<0.05);两组术后1、2、3年的生存率、无瘤生存率比较,差异均无统计学意义(P>0.05)。结论:腹腔镜下子宫广泛性切除术可降低子宫颈癌患者血清TNF-α及SIL-2R表达水平,加快术后恢复。
Objective:To investigate the effect of laparoscopic radical hysterectomy on the expression of tumor necrosis factorα(TNF-α)and soluble interleukin-2 receptor(SIL-2R)in patients with cervical cancer.Method:A total of 63 patients with cervical cancer were selected as observation objects.According to the treatment methods,patients were divided into control group(30 cases)and observation group(33 cases).The control group received open radical hysterectomy and the observation group received laparoscopic radical hysterectomy.The general surgical conditions,complications,serum levels of TNF-αand SIL-2R,prognosis of the two groups were compared.Result:The operation time of the observation group was longer than that of the control group,the blood loss was less than that of the control group,the postoperative exhaust time and the recovery time of urination function were shorter than those of the control group(P<0.05).There were no statistically significant differences in the number of lymph nodes removed,the length of left and right paracentric resection,and the length of vaginal resection between the two groups(P>0.05).After the operation,the serum levels of TNF-αand SIL-2R in the two groups were lower than those before the operation(P<0.05),but there were no statistically significant differences between the two groups in serum levels of TNF-αand SIL-2R after the operation(P>0.05).The complication rate in the observation group was lower than that in the control group(P<0.05).The survival rate and tumor-free survival rate at 1,2 and 3 years after the operation of the two groups were compared,the differences were not statistically significant(P>0.05).Conclusion:Laparoscopic radical hysterectomy can reduce the expression level of serum TNF-αand SIL-2R in cervical cancer patients,accelerate postoperative recovery.
作者
闫喜秋
YAN Xiqiu(Jiamusi Maternal and Child Health Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2020年第8期6-9,共4页
Medical Innovation of China
