摘要
目的应用倾向性评分方法分析脉血康胶囊对冠心病治疗结局的影响。方法基于22家三级甲等医院的电子医疗病历数据库,对使用和未使用脉血康胶囊的冠心病患者按照标准进行1∶1匹配。匹配后使用脉血康胶囊患者组(A组)与未使用脉血康胶囊(B组)均为2464例。将数据库中治疗结局为"痊愈"和"好转"的重新合并定义为治疗有效,将"无效"、"死亡"和"其他"合并为治疗无效人群,应用倾向性评分方法对重新合并后两组的治疗结局有效性进行比较。结果χ~2检验结果显示,在未控制混杂因素的情况下,两组的有效率比较差异有统计学意义(P<0.05),A组较B组治疗效果好。为进一步观察两组患者疗效的差别,分别通过三种logistic回归分析方法进行分析,均显示回归系数大于0,且差异均有统计学意义(P<0.01)。结论使用脉血康胶囊的冠心病患者较不使用该药的冠心病患者的治疗有效率高,脉血康胶囊可提高冠心病的临床疗效。
Objective To analyze the effect of Maixuekang Capsule on the treatment outcome of coronary heart disease(CHD)by propensity score.Methods Based on the electronic medical record database of 22 large-scale tertiary hospitals nationwide,this study matched the coronary heart disease patients using and not using Maixuekang capsule according to a certain standard(1∶1).After matching,there were 2464 cases in the patients group(group A)and the patients group(group B).In the database,the recombination of"recovery"and"improvement"is defined as effective treatment,and"invalid","death"and"other"are combined as ineffective treatment population.The effectiveness of the two groups after the re combination is compared by propensity score.Results The results ofχ~2 test showed that the difference between the two groups was statistically significant(P<0.05)without controlling the confounding factors,and the treatment effect of group A was better than that of group B.In order to further observe the difference between the two groups,three logistic regression analysis methods were used to analyze,which showed that the regression coefficient was>0,and there was statistical significance(P<0.01).Conclusions The therapeutic effect of Maixuekang capsule on coronary heart disease is higher than that of patients without the drug.
作者
陈仁波
盖国忠
张文丽
庄严
谢雁鸣
Chen Renbo;Gai Guozhong;Zhang Wenli;Zhuang Yan;Xie Yanming(Institute of Clinical Basic Medicine,Chinese Academy of Chinese Medical Sciences,Beijing 100700,China;School of Statistics,Renmin University of China,Beijing 100872,China;Navy PLA General Hospital,Beijing 100048,China)
出处
《中国医师杂志》
CAS
2020年第3期365-368,共4页
Journal of Chinese Physician
基金
中医药行业科研专项项目(201507003-8)
中国中医科学院基本科研业务费自主选题项目(Z0439)。
关键词
倾向性评分
脉血康胶囊
冠心病
电子健康病历
Propensity score
Maixuekang capsule
Coronary disease
Electronic health records
