摘要
目的分析颈动脉狭窄与急性脑梗死患者同型半胱氨酸(Hcy)、血小板参数及预后的相关性。方法2017年1月至2019年5月我院收治的97例急性脑梗死患者(梗死组),并选取同期进行健康体检者30例(健康组)。所有急性脑梗死患者均进行相应治疗及3个月后随访,比较两组血清中Hcy、血小板参数水平,以及不同程度颈动脉狭窄急性脑梗死患者血小板参数、Hcy水平,分析与预后的相关性。结果梗死组血清中Hcy、血小板平均体积(MPV)、血小板分布宽度(PDW)明显高于健康组,PLT低于健康组(P<0.05);不同程度颈动脉狭窄急性脑梗死患者PLT、PDW、血小板压积(PCT)比较差异无统计学意义(P>0.05);重度狭窄患者MPV值、Hcy值高于无或轻度狭窄、中度狭窄者(P<0.05)。不同程度动脉狭窄急性脑梗死患者预后存在明显差异,重度狭窄患者3个月出不良转归、神经恶化、死亡率高于无或轻度狭窄、中度狭窄者(P<0.05)。多元Logistic回归分析:颈动脉狭窄与急性脑梗死患者Hcy、血小板参数及预后存在相关性,颈动脉狭窄程度越高,患者Hcy水平及MPV表达水平越高,预后情况差(P<0.05)。结论颈动脉狭窄与急性脑梗死患者Hcy、血小板参数及预后存在相关性,颈动脉狭窄越严重患者预后越差,在临床上早期干预患者颈动脉狭窄情况可能会对患者预后有所改善。
Objective To analyze the correlation between carotid artery stenosis and Hcy,platelet parameters and prognosis of patients with acute cerebral infarction.Methods The clinical data of 97 patients with acute cerebral infarction(infarction group)admitted to our hospital from January 2017 to May 2019 were retrospectively analyzed,and 30 patients with healthy physical examination at the same term were selected as control group.All patients with acute cerebral infarction were treated with corresponding treatment and followed up after 3 months of treatment.The levels of Hcy and platelet parameters in serum were compared between the two groups.The levels of platelet parameters and Hcy of patients with different degrees of carotid artery stenosis were also compared and the correlation with prognosis was analyzed.Results The levels of serum Hcy,MPV and PDW in the infarction group were significantly higher than those in the healthy group,but the PLT was lower than that in the healthy group(P<0.05).There was no significant difference in PLT,PDW and PCT between the patients with different degrees of carotid artery stenosis(P>0.05).The MPV and Hcy values of patients with severe stenosis were higher than those of patients without stenosis or with mild or moderate stenosis(P<0.05).The prognosis of the patients with different degrees of carotid artery stenosis was significantly different,in which the incidence of adverse outcome,neurological deterioration,and mortality in the patients with severe stenosis was higher than that in the patients without stenosis or with mild or moderate stenosis(P<0.05).Multivariate logistic regression analysis showed that carotid stenosis was correlated to Hcy,platelet parameters and prognosis in patients with acute cerebral infarction.The higher the degree of carotid stenosis and of the expression levels of Hcy and MPV were,the worse the prognosis was(P<0.05).Conclusion Carotid stenosis was correlated to Hcy,platelet parameters and prognosis in patients with acute cerebral infarction.The more severe the carotid stenosis is,the worse the prognosis of patients is.The early intervention of carotid stenosis in patients may improve the prognosis of the patients.
作者
佟家旭
姜学明
刘莹莹
TONG Jia-xu;JIANG Xue-ming;LIU Ying-ying(Liaoyang Third People's Hospital,Liaoyang 111000,China)
出处
《实用医院临床杂志》
2020年第2期119-122,共4页
Practical Journal of Clinical Medicine
基金
辽宁省自然科学基金资助项目(编号:201602001)。
