摘要
目的探讨美多巴联合普拉克索用药方案在老年帕金森病患者非运动症状中的治疗效果。方法选取2015年10月-2019年8月期间武陟县人民医院收治的112例老年帕金森病患者,随机分组,观察组56例患者给予美多巴联合普拉克索用药方案,对照组56例患者单纯采用美多巴,对比两组患者临床疗效。结果观察组患者治疗总有效率75.5%高于对照组37.5%(P<0.05);观察组治疗后匹兹堡睡眠质量(PSQI)评分、非运动症状(NMSQuest)评分均优于对照组(P<0.05);观察组治疗后血尿酸水平改善程度优于对照组(P<0.05);观察组症状改善时间低于对照组(P<0.05),但两组不良反应对比无显著差异(P>0.05)。结论美多巴联合普拉克索用药方案临床效果显著,可提高老年帕金森病患者疗效,改善非运动症状和血尿酸水平,是安全有效的联合用药方案。
Objective To explore the therapeutic effect of medopa combined with pramipexole in the treatment of nonmotor symptoms in elderly Parkinson’s disease patients.Methods 112 elderly Parkinson’s disease patients who were treated in Wuzhi County People’s Hospital from October 2015 to August 2019 were randomly divided into two groups.56 patients in the control group were given medopa,and 56 patients in the observation group were given medopa plus pramipexole.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher(75.5%)than that in the control group(P<0.05).The Pittsburgh sleep quality(PSQI)score and non-motor symptoms(NMSQuest)score in the observation group were better than those in the control group(P<0.05);The improvement of blood uric acid level in the observation group was better than that in the control group(P<0.05);the improvement of symptoms in the observation group was faster than that in the control group(P<0.05),but there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of medoca and pramipexole has significant clinical effects,can improve non-motor symptoms and blood uric acid level in elderly patients with Parkinson’s disease,and is a safe and effective.
作者
范卫平
FAN Weiping(Department of Neurology,Wuzhi County People's Hospital,Wuzhi Henan 454950,China)
出处
《临床研究》
2020年第3期33-34,共2页
Clinical Research
关键词
美多巴
普拉克索
老年帕金森病
非运动症状
medopa
pramipexole
elderly Parkinson's disease
non-motor symptoms
