摘要
目的观察阿维A联合中药治疗脓疱型银屑病的疗效。方法选择长治市第二人民医院2011年7月至2017年10月收治的脓疱型银屑病患者91例,采用随机数字表法分为治疗组31例、对照组Ⅰ30例与对照组Ⅱ30例,三组在基础治疗的同时分别采用阿维A联合中药、单纯阿维A口服、单纯服中药治疗,对比三组患者的疗效、体温下降时间、脓疱完全消退时间以及住院时间。结果治疗组总有效率93.55%(29/31),对照组Ⅰ70.00%(21/30),对照组Ⅱ73.33%(22/30),治疗组明显高于两个对照组(χ^2=5.720、4.546,均P<0.05),对照组I和对照组Ⅱ总有效率差异无统计学意义(P>0.05);治疗组体温下降时间(4.24±0.86)d、脓疱完全消退时间(7.38±0.72)d、住院时间(23.46±0.61)d,对照组I分别为(7.45±0.92)d、(10.45±0.52)d、(30.01±0.82)d,对照组Ⅱ分别为(8.56±0.78)d、(11.56±0.35)d、(31.53±0.68)d,对照组I显著短于对照组Ⅱ(t=14.083、19.037、35.476,均P<0.05),治疗组均显著短于对照组Ⅰ、对照组Ⅱ(t=20.529、28.682、48.826,5.041、9.699、7.816,均P<0.05)。结论阿维A胶囊联合中药治疗脓疱型银屑病临床疗效好、显效快,可在较短时间内控制体温,缩短脓疱消退时间,同时可有效缩短住院时间。
Objective To observe the efficacy of acitretin combined with traditional Chinese medicine in the treatment of pustular psoriasis.Methods From July 2011 to October 2017,91 patients with pustular psoriasis admitted to the Second People's Hospital of Changzhi were randomly divided into treatment group(n=31),control groupⅠ(n=30)and control groupⅡ(n=30)according to the digital table.The patients in the three groups were treated with acitretin combined with traditional Chinese medicine,oral acitretin and traditional Chinese medicine,respectively.The therapeutic effects,the time required for hypothermia,the time required for the complete disappearance of pustules and the average length of hospitalization were compared among the three groups.Results The total effective rate was 93.55%(29/31)in the treatment group,70.00%(21/30)in the control groupⅠand 73.33%(22/30)in the control groupⅡ.The total effective rate in the treatment group was significantly higher than that in the two control groups(χ^2=5.720,4.546,all P<0.05).There was no statistically significant difference in total effective rate between the control groupⅠand the control groupⅡ(P>0.05).The fever allaying time,completely disappearance time of pustules,average hospital stay in the treatment group were(4.24±0.86)d,(7.38±0.72)d,(23.46±0.61)d,respectively,which in the control groupⅠwere(7.45±0.92)d,(10.45±0.52)d,(30.01±0.82)d,respectively,which in the control groupⅡwere(8.56±0.78)d,(11.56±0.35)d,(31.53±0.68)d,respectively,which in the control groupⅠwere significantly shorter than those in the control groupⅡ(t=14.083,19.037,35.476,all P<0.05),which in the treatment group were significantly lower than those in the control groupⅠand the control groupⅡ(t=20.529,28.682,48.826,5.041,9.699,7.816,all P<0.05).Conclusion Acitretin capsule combined with traditional Chinese medicine is effective in the treatment of pustular psoriasis,which can control body temperature in a short time,shorten the time of disappearance of pustule,relieve the pain of patients,and shorten the time of hospitalization at the same time.
作者
秦凌花
Qin Linghua(Department of Dermatology,the Second People's Hospital of Changzhi,Changzhi,Shanxi 046000,China)
出处
《中国基层医药》
CAS
2020年第5期568-571,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
山西省卫生和计划生育委员会中医科研课题(2014ZY07)。
关键词
银屑病
皮肤疾病
阿维A
中草药
药物疗法
联合
治疗结果
对比研究
Psoriasis
Skin diseases
Avera
Drugs
chinese herbal
Drug therapy
combination
Treatment outcome
Comparative study
