摘要
趋化因子配体5(CCL5)是趋化性细胞因子CC亚族成员之一,参与细胞增殖、炎性反应、变态反应及肿瘤的生长和转移等过程。CCL5与其受体(CCR5)组成的生物轴是乳腺癌侵袭及转移的重要调节机制。上皮-间质转化(EMT)是近来研究癌细胞浸润和转移的重要机制。本文对CCL5-CCR5生物轴与EMT在乳腺癌转移中的最新进展进行综述。
Chemokines ligand 5(CCL5)is a member of the CC subfamily of chemokines,and is involved in cell proliferation,inflammatory response,allergy and tumor growth and metastasis.The biological axis composed of CCL5 and its receptor(CCR5)is an important regulatory mechanism for breast cancer invasion and metastasis.Epithelial-mesenchy-mal transition(EMT)is an important mechanism for the recent study of cancer cell invasion and metastasis.This article reviews the latest progress of CCL5-CCR5 biological axis and EMT in breast cancer metastasis.
作者
曹卫刚
杨振林
CAO Wei-gang;YANG Zhen-lin(Thyroid and Breast Surgery Depatment,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China)
出处
《临床医学研究与实践》
2020年第10期189-190,共2页
Clinical Research and Practice
基金
山东省自然科学基金(No.ZR2017MH033)
烟台市科技计划项目(No.2019YD063)
滨州医学院校级科技计划项目(No.BY2018KJ31)。
关键词
趋化因子
乳腺癌
上皮-间质转化
chemokines
breast cancer
epithelial-mesenchymal transition
