摘要
感音神经性聋(sensorineural hearing loss,SNHL)是由耳蜗毛细胞(HCs)和螺旋神经元(spiral ganglion neurons,SGNs)的丢失或损伤引起的,是全世界常见的一种听力损失,影响着数百万人。目前很少有治疗听力损失的方法,因此,有必要开发新的治疗方法来帮助数百万听力障碍患者。近年来,基因与干细胞研究在涉及感音神经的领域取得了巨大进展,这一技术的进步为治疗听力损失的患者提供了一线希望。本综述讨论了利用基因和干细胞疗法替换丢失的感觉和神经细胞来治疗感音神经性听力损失的研究现状,并探讨了当前阻碍其临床应用的可能障碍和局限性。
Sensorineural hearing loss(SNHL)results from loss of or damage to the cochlear hair cells(HCs)and spiral ganglion neurons(SGNs).It is a common form of hearing loss worldwide,affecting millions of people.At present,there are very few therapies currently available to treat SNHL.Thus,there is a need to develop new therapeutic methods to aid millions of people suffering from hearing impairment.In recent years,great progress has been made in the field of gene and stem cell research involving the auditory sensory nerve,which provides a glimmer of hope for the treatment of patients with SNHL.This paper details the current status of gene and stem cell therapy to replace lost sensory and neural cells in the treatment of sensorineural hearing loss,and describes the possible obstacles and limitations that hinder their clinical application.
作者
王新兰
田海月
钟翠萍
向大伟
WANG Xinlan;TIAN Haiyue;ZHONG Cuiping;XIANG Dawei(Department of Otolaryngology-Head and Neck Surgery,the 940th Hospital of the Joint Logistics Support Unit of the Chinese PLA,Lanzhou 730050,China;Graduate School of Clinical Medicine,Ningxia Medical University,Yinchuan,750004;The 940th Hospital of the Joint Logistics Support Unit of the Chinese PLA,Lanzhou,730050)
出处
《中华耳科学杂志》
CSCD
北大核心
2020年第2期404-408,共5页
Chinese Journal of Otology
基金
甘肃省重点研发计划项目(18YF1FA132)
甘肃省卫生行业科研计划项目(GSWGKY8-25)
2018年度军队医学科技青年培育计划项目(18QNP047)。
关键词
感音神经性聋
基因
干细胞
Sensorineural hearing loss
Gene
Stem cells
