摘要
目的:探讨辛伐他汀对冠心病心绞痛患者血管内皮功能及血液流变学的影响。方法:选择2015年1月至2017年2月我院收治的冠心病心绞痛患者84例,采用随机数字表法将患者分为实验组与对照组,各42例。对照组患者采用常规方案治疗,实验组患者在此基础上联合辛伐他汀治疗,比较两者患者血管内皮功能及血液流变学指标。结果:实验组治疗后的心绞痛发作频次(3.14±0.32)次/周、持续时间(3.05±0.46)次/min少于对照组,CK-MB(32.15±5.32)ug/L、LDH(147.21±13.22)ug/L、CRP(4.02±0.59)mg/L、FIB(3.11±0.52)g/L水平低于对照组,两组比较差异具有统计学意义(P<0.05)。实验组患者治疗后的ET(55.42±2.92)ng/L、TXB2(93.23±6.26)ng/L水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。实验组患者治疗后的全血黏度、血浆黏度、红细胞积压、纤维蛋白原水平明显低于对照组(P<0.05)。结论:辛伐他汀治疗可有效改善冠心病心绞痛患者的血管内皮功能及血液流变学指标,疗效确切,值得推荐。
Objective:To investigate the effects of simvastatin on vascular endothelial function and hemorheology in patients with coronary heart disease and angina pectoris.Methods:84 patients with coronary heart disease and angina pectoris admitted to our hospital from January 2015 to February 2017 were selected.The patients were divided into experimental group and control group by random number table method,42 cases in each group.Patients in the control group were treated with routine regimen,while patients in the experimental group were treated with simvastatin on the basis of routine regimen.The vascular endothelial function and hemorheological parameters were compared between the two groups.Results:After treatment,the frequency and duration of angina pectoris attacks in the experimental group were less than those in the control group(3.14(+0.32)times/week) and(3.05(+0.46)times/min),CK-MB(32.15(+5.32)ug/L),LDH(147.21(+13.22)ug/L),CRP(4.02(+0.59)mg/L) and FIB(3.11(+0.52)g/L) levels were lower than those in the control group,and there were significant differences between the two groups.(P<0.05).The levels of ET(55.42+2.92)ng/L and TXB2(93.23+6.26)ng/L in the experimental group were significantly lower than those in the control group after treatment,with a significant difference between the two groups(P<0.05).The whole blood viscosity,plasma viscosity,hematocrit and fibrinogen levels in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:Simvastatin can effectively improve vascular endothelial function and hemorheological parameters in patients with coronary heart disease and angina pectoris.It is effective and worth recommending.
作者
吕丹
金大鹏
王文丰
王鹏飞
LV Dan;JIN Dapeng;WANG Wenfeng(The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China)
出处
《河北医学》
CAS
2020年第4期568-571,共4页
Hebei Medicine
基金
河北省承德市科技支撑计划项目,(编号:201801A051)。
关键词
冠心病心绞痛
辛伐他汀
血管内皮功能
血液流变学
Coronary heart disease and angina pectoris
Simvastatin
Vascular endothelial function
Hemorheology
