摘要
目的探究小剂量红霉素联合多潘立酮治疗小儿功能性消化不良的疗效及安全性。方法选取2017年10月至2018年10月于重庆三峡中心医院江南分院接受治疗的功能性消化不良患儿100例,随机分为多潘立酮组与联合治疗组,多潘立酮组使用多潘立酮进行治疗,联合治疗组使用小剂量红霉素联合多潘立酮进行治疗。比较2组患儿临床症状消失时间,胃动力学相关指标,血清胃动素、胃泌素、一氧化氮(nitric oxide,NO)、5-羟色胺(5-hydroxytryptamine,5-HT)水平,临床疗效,胃电节律异常、胃动过缓发生情况以及不良反应发生情况。结果治疗后,联合治疗组患儿食欲不振、恶心呕吐、腹胀、腹痛等临床症状消失时间均显著低于多潘立酮组(P<0.05);联合治疗组患儿胃窦收缩频率、胃窦收缩幅度、胃窦运动指数水平均显著高于多潘立酮组(P<0.05);联合治疗组胃动素、胃泌素、NO、5-HT水平均显著高于多潘立酮组(P<0.05);联合治疗组患儿治疗总有效率(94.00%)显著高于多潘立酮组(80.00%)(P<0.05);联合治疗组患儿胃电节律异常、胃动过缓发生率显著低于多潘立酮组(P<0.05)。联合治疗组患儿不良反应发生率略高于多潘立酮组,但差异无统计学意义(P>0.05)。结论小剂量红霉素联合多潘立酮治疗小儿功能性消化不良,能够明显缩短患儿临床症状消失时间,改善胃动力,调控胃动素、胃泌素、NO、5-HT水平,治疗效果显著且安全性较高。
Objective To explore the efficacy and safety of low dose erythromycin combined with domperidone in the treatment of functional dyspepsia in children.Methods A total of 100 children with functional dyspepsia who were treated in Jiangnan Branch of Chongqing Three Gorges Central Hospital from October 2017 to October 2018 were randomly divided into domperidone group and combined treatment group.The children in domperidone group were treated with domperidone,while those in the combined treatment group were treated with low-dose erythromycin and domperidone.The disappearance time of clinical symptoms,the related indexes of gastric dynamics,serum motilin,gastrin,nitric oxide(NO)and 5-hydroxytryptamine(5-HT),clinical curative effect,abnormal gastric electrical rhythm,occurrence of bradykinesia and adverse reactions were compared between the two groups.Results The disappearance time of clinical symptoms such as anorexia,nausea and vomiting,abdominal distension and abdominal pain in the combined treatment group was significantly shorter than that in the domperidone group(P<0.05);the frequency,amplitude and motility index of gastric antrum in the combined treatment group were significantly higher than those in the domperidone group(P<0.05);the serum levels of motilin,gastrin,NO and5-HT in the combined treatment group were significantly higher than those in the domperidone group(P<0.05);the over all effective rate of combined treatment group(94.00%)was significantly higher than that of domperidone group(80.00%)(P<0.05);the incidence of abnormal gastric rhythm and slow gastric motility in the combined treatment group was significantly lower than that in the domperidone group(P<0.05).The incidence of adverse reactions in the combined treatment group was slightly higher than that in the domperidone group,but there was no significant difference(P>0.05).Conclusion The use of low dose erythromycin combined with domperidone can significantly shorten the time of disappearance of clinical symptoms,improve gastrointestinal motility,and regulate the levels of motilin,gastrin,NO and 5-HT in children with functional dyspepsia.The treatment effect is significant and safe.
作者
何远娜
李罗碧
HE Yuan-na;LI Luo-bi(Digestive Ward for Children,Jiangnan Branch of Chongqing Three Gorges Central Hospital,Chongqing 404000,China)
出处
《临床药物治疗杂志》
2020年第3期42-46,共5页
Clinical Medication Journal
关键词
红霉素
多潘立酮
功能性消化不良
胃肠动力
erythromycin
domperidone
functional dyspepsia
gastrointestinal motility
