摘要
目的:探讨皮肤链格孢病的临床特征、诊断、治疗及预后。方法:对我院近两年收治的2例皮肤链格孢病进行总结,并检索国内万方数据库和中国知网数据库和近10年国外Pubmed数据库报告的皮肤链格孢病,共60例,进行文献分析。结果:共2例患者,男、女各1例,均有肾病综合症口服免疫制剂病史,通过组织病理检查和真菌培养确诊,并通过分子生物学方法确诊为链互隔孢(Alternaria alternate)引起的皮肤链格孢病。1例给予手术切除联合伊曲康唑治疗后失访,1例给予口服伊曲康唑及他克莫司减量治疗,随访1年,未复发。结论:免疫功能低下是皮肤链格孢病的危险因素,组织病理检查和真菌培养为主要确诊手段,治疗主要为系统应用伊曲康唑或联合其他治疗。
Objective: To study the clinical features, diagnosis, treatment and prognosis of cutaneous alternariosis. Methods:We summarized two cases of cutaneous alternariosis who were admitted and treated in our hospital in the past two years. A literature review of sixty cases of cutaneous alternariosis published in domestic Wan-fang database, CNKI database and foreign Pubmed database in the past 10 years was also discussed. Results: Both patients, 1 male and 1 female, had a history of oral immunosuppressive treatment for nephrotic syndrome. A diagnosis of cutaneous alternariosis of both patients was confirmed by histopathology,fungus culture, as well as molecular testing. One case was lost for follow-up after receiving surgical resection in combination with itraconazole. Case 2 was treated with oral antifungal itraconazole and continued on her/his immunosuppressive tacrolimus at lower dose. The patient was followed after one year without recurrence. Conclusion: Immunocompromised condition is the risk factor of cutaneous alternariosis. A definite diagnosis requires histopathological examination and fungus culture. The treatment is mainly using systematic antifungal itraconzole or in combination with other treatment options.
作者
郭艳阳
薛小文
朱振来
赖绮雯
马翠玲
王刚
付萌
GUO Yan-yang;XUE Xiao-wen;ZHU Zhen-lai;LAI Qi-wen;MA Cui-ling;WANG Gang;FU Meng(Department of Dermatology,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2020年第3期145-149,共5页
Journal of Clinical Dermatology
基金
陕西省自然科学基金(20144091)资助项目。
关键词
链格孢病
皮肤
alternariosis
cutaneous
