摘要
目的:探讨马来酸麦角新碱联合卡贝缩宫素预防瘢痕子宫妊娠产后出血效果及对凝血功能影响。方法:选取2016年1月30日-2019年4月30日本院收治的计划剖宫产瘢痕子宫产妇150例,随机数字表方法分为3组各50例。马来酸组接受马来酸麦角新碱预防出血,卡贝组接受卡贝缩宫素预防出血,联合组接受马来酸麦角新碱联合卡贝缩宫素预防出血。比较各组疗效、术中及术后出血量、术后1d、3d、5d子宫下降幅度、剖宫产前后血凝血指标变化以及不良反应发生率。结果:联合组总有效率(96.0%)高于另外两组(P<0.05)。术中出血量各组无差异(P>0.05),术后24h出血量联合组<马来酸组<卡贝组(P<0.05)。术后24h联合组Hb(112.7±9.1 g/L)和纤维蛋白原(5.9±1.3)高于另外两组,D-二聚体(3.1±0.8)低于另外两组(P<0.05)。术后1d、3d、5d联合组子宫下降幅度大于另外两组(P均<0.05)。各组不良反应发生率(8.0%、8.0%、10.0%)无差异(P>0.05)。结论:马来酸麦角新碱联合卡贝缩宫素可更有效预防瘢痕子宫再妊娠术中及产后出血,且可促进子宫下降,改善凝血功能。
Objective:To investigate the effect of ergometrine maleate combined with carbetocin for preventing postpartum hemorrhage of women with scar uterus pregnancy,and to study its influence on the blood coagulation function of women.Methods:150 women with scar uterus pregnancy who wanted to cesarean section were selected and were divided into 3 groups according to the random number table method from January 30,2016 to April 30,2019(50 cases in each group).The women in group A were given ergometrine maleate for preventing postpartum hemorrhage,the women in group B were given carbetocin for preventing postpartum hemorrhage,and the women in group C were given ergometrine maleate combined with carbetocin for preventing postpartum hemorrhage.The efficacy,intraoperative and postoperative bleeding volume,the change of uterine fundal height on the 1st,3rd,and 5th days after cesarean section,the levels of blood coagulation parameters(D-dimer and Fibrinogen)before and after cesarean section,and the incidence of adverse reactions of women were compared among the three groups.Results:The total effective rate of women in group C was 96.0%,which was significant higher than that of women in group A and B(P<0.05).The 24h postoperative bleeding volume in group A was significant lower than that in group B(p<0.05).There was no significant different in the amount of intraoperative blood loss of women among the 3 groups(P>0.05).The postoperative bleeding volume in 24h of women in group C was the lowest,but that of women in group B was the highest.24h after cesarean section,Hb value and fibrinogen level of women in group C were 112.7±9.1g/L and 5.9±1.3,which were significant higher than those of women in group A and B,but the d-dimer level(3.1±0.8)of women in group C was significant lower(P<0.05).The degree of decreasing of uterine fundal height on the 1st,3rd,and 5th days after cesarean section of women in group C was significant more than that of women in group A and B(P<0.05).The incidence of adverse reactions of women in the three groups was 8.0%,8.0%,and 10.0%,respectively,which had no significant difference(P>0.05).Conclusion:Ergometine maleate combined with carbetocin can effectively prevent intraoperative and postpartum hemorrhage of women with scar uterus pregnancy,and can promote uterine the decline of uterine fundal height,and can improve coagulation function of women.
作者
贾源君
焦娜
JIA Yuanjun;JIAO Na(The First Affiliated Hospital of Henan University of Science and Technology, Henan Province, 471000)
出处
《中国计划生育学杂志》
2020年第3期345-348,共4页
Chinese Journal of Family Planning
基金
河南省洛阳市科技计划项目(1201052A-2)。
