摘要
目的探讨外周血中性粒细胞绝对计数(NEU)、淋巴细胞绝对计数(LYM)、单核细胞绝对计数(MON)、血小板绝对计数(PLT)、红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)在原发性干燥综合征(pSS)疾病活动性评价中的意义。方法对2017年12月至2018年12月初诊的72例pSS患者的临床表现以及实验室检查指标进行回顾性整理研究,依据ESSDAI评分高低将患者分为疾病活动组(26例,ESSDAI>4分)和非活动组(46例,ESSDAI≤4分),比较2组患者NEU、LYM、MON、PLT、RDW、NLR、PLR是否有差异,进一步分析其中有统计学意义的指标与红细胞沉降率(ESR)、C-反应蛋白(CRP)等炎症标志物及球蛋白(GLB)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)、CD4/CD8等免疫标志物的相关性,并绘制ROC曲线,评估各指标判断原发性干燥综合征疾病活动性的灵敏度和特异度。结果活动组RDW、NLR、PLR均高于非活动组(P<0.05),其中NLR、PLR与GLB及IgG呈负相关(P<0.05),RDW与IgA呈正相关(P<0.05),ROC曲线分析结果表明NLR对原发性干燥综合征疾病活动性的评价能力优于其他指标。结论RDW、NLR、PLR对pSS疾病的活动性有一定的评价作用。
Objective To investigate the significance of neutrophil count(NEU),lymphocyte count(LYM),monocyte count(MON),platelet count(PLT),red blood cell distribution width(RDW),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)in evaluating the activity of primary Sj?gren’s syndrome.Methods The clinical data and laboratory examination results about 72 patients with primary Sj?gren’s syndrome retrospectively analyzed.According to ESSDAI scores,these patients were divided into active disease group(n=26,ESSDAI>4)and inactive disease group(n=46,ESSDAI≤4).The NEU,MON,LYM,PLT,RDW,NLR and PLR were observed and compared between the two groups.Spearman rank correlation analysis was used to analyze the correlation among RDW,NLR,PLR and other indexes including erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),globulin(GLB),Immunoglobulin G(IgG),Immunoglobulin M(IgM),immunoglobulin A(IgA),complement 3(C3),complement 4(C4)and CD4/CD8.The ROC curve was drawn to analyze the sensitivity and specificity of these indexes in evaluating the activity of primary Sj?gren’s syndrome.Results The levels of RDW,NLR and PLR in active disease group were significantly higher than those in inactive disease group(P<0.05),in which,RDW was positively correlated with IgA,however,NLR and PLR were negatively correlated with globulin and IgG(P<0.05).ROC curve analysis showed that NLR had a more important significance than the other indexes in evaluating the activity of primary Sj?gren’s syndrome.Conclusion RDW,NLR and PLR may play certain role in evaluating the activity of primary Sj?gren’s syndrome.
作者
马香书
于芳
于悦卿
马倩
李金丫
柴国静
赵培
帖彦清
MA Xiangshu;YU Fang;YU Yueqing(Department of Clinical Laboratory,Hebei, Provincial People’s Hospital,Hebei, Shijiazhuang 050051,China)
出处
《河北医药》
CAS
2020年第7期1028-1031,共4页
Hebei Medical Journal
基金
河北省医学科学研究重点课题(编号:20190352)。
