摘要
目的:分析急性T淋巴细胞白血病(T-ALL)患者免疫分型结果,提高对早期前体T淋巴细胞白血病(ETP-ALL)及CD5增高的ETP ALL(near ETP ALL)的认识。方法:回顾性分析62例于本院诊治的初诊成人T-ALL患者的免疫分型结果,根据CD5、CD1a、CD8及髓/干(My/S)抗原的表达情况,将其分为ETP,near ETP及非ETP(non-ETP)3组,对比分析3组患者免疫分型特点及临床基本资料。结果:3组间年龄、白细胞数和血小板计数及骨髓白血病细胞百分比均有显著差异(P<0.05),ETP组及near ETP组均主要见于pro T及pre T,non-ETP组主要见于皮质T及成熟T。3组间My/S,CD1a,CD8及CD5阳性率均具有显著差异(P<0.001)。non-ETP组CD4及CD3阳性率均显著高于ETP组及near-ETP组(P<0.01)。near-ETP组CD56阳性率(50%)显著高于ETP组(16.7%)及non-ETP组(0%)(P<0.01)。结论:根据CD5、CD1a、CD8及髓/干(My/S)抗原的表达情况,可以将T-ALL分为ETP、near ETP及non-ETP 3组,3组间免疫分型及临床基本资料有统计学差异。
Objective:To analyze the results of immunophenotyping in patients with acute T-lymphoblastic leukemia(T-ALL)so as to improve the understanding of early T-cell precursor acute T-lymphoblastic leukemia(ETP-ALL)and near ETP-ALL with elevated CD5.Methods:The results of immunophenotypes in 62 patients with newly diagnosed adult T-ALL in our hospital were retrospectively analyzed.According to the expression of CD5,CD1 a,CD8 and My/S antigens,the patients were divided into 3 groups:ETP,near ETP and non-ETP.The immunophenotypic characteristics and basic clinical data of three groups were compared and analyzed.Results:There were significant differences in age,white blood cell and plt counts as well as percentage of bone marrow blasts among three groups(P<0.05).ETP and near ETP mainly belonged to Pro T and pre T,and non-ETP mainly belonged to cortical T and mature T.The positive rates of My/S,CD1 a,CD8 and CD5 were significantly different among three groups(P<0.01).The positive rates of CD4 and CD3 in non-ETP group were significantly higher than those in ETP and near-ETP group(P<0.01).The positive rate of CD56 in near-ETP group was 50%,which was significantly higher than that in ETP group(16.7%)and non-ETP group(0%)(P<0.01).Conclusion:According to the expression of CD5,CD1 a,CD8 and My/S antigens,T-ALL patients can be divided into three groups:ETP,near ETP and non ETP,the immunophenotypes and basic clinical data among 3 groups are statistically different.
作者
林娜
刘正华
王萍萍
富威
颜晓菁
李艳
LIN Na;LIU Zheng-Hua;WANG Ping-Ping;FU Wei;YAN Xiao-Jing;LI Yan(Department of Hematology,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2020年第2期442-445,共4页
Journal of Experimental Hematology
基金
辽宁省科技计划项目(2013225079),“万人计划”青年拔尖人才。
关键词
急性T淋巴细胞白血病
早期前体T淋巴细胞白血病
免疫表型
acute T lymphoblastic leukemia(T-ALL)
early T-cell precursor acute lymphoblastic leukemia(ETP-ALL)
immunophenotype
